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Natural history and treatment with ursodiol of gallstones formed during rapid loss of weight in man

Cholesterol gallstones form frequently among obese patients during rapid loss of weight. The aims of the present study were to determine the short-term natural history of these gallstones and the efficacy of ursodiol for their dissolution. Twenty-two patients whose gallstones had formed during rapid loss of weight were randomized in double-masked fashion to either ursodiol, 1200 mg/day, or placebo for nine months. Ultrasonography of the gallbladder was performed after three and nine months of treatment. All patients without disappearance of their gallstones after nine months received open-label ursodiol for an additional nine months with ultrasonography after three and nine months. Among the patients completing three months of masked treatment, disappearance of gallstones was seen in five of 11 patients who received placebo and four of seven patients who received ursodiol. Only one additional patient of six continuing placebo for nine months experienced disappearance. Neither of two patients continuing ursodiol for nine months had disappearance of gallstones. None of the five patients treated with open-label ursodiol for nine months had disappearance of gallstones. Thus, half of the gallstones that form during rapid loss of weight disappear rapidly once loss of weight ceases; ursodiol may not increase the frequency or rapidity of their disappearance.

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1. From the Division of Gastroenterology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, UCLA School of Medicine, USA

   Jay W. Marks MD, Theodore Stein MD & Leslie J. Schoenfield MD, PhD

1. Jay W. Marks MD
2. Theodore Stein MD
3. Leslie J. Schoenfield MD, PhD

This project was supported by the National Institute of Diabetes, Digestive and Kidney Diseases, grant AM 37080, and Ciba-Geigy Corporation.

Marks, J.W., Stein, T. & Schoenfield, L.J. Natural history and treatment with ursodiol of gallstones formed during rapid loss of weight in man. Digest Dis Sci 39, 1981–1984 (1994). https://doi.org/10.1007/BF02088135

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• Received: 25 October 1993

• Revised: 22 January 1994

• Accepted: 04 February 1994

• Issue Date: September 1994

• DOI: https://doi.org/10.1007/BF02088135

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