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Biosynthesis of roquefortine and 3,12-dihydroroquefortine by the culture Penicillium farinosum

A new culturePenicillium farinosum synthesizing roquefortine and 3, 12-dihydroroquefortine was found. UnlikeP. roqueforti, a known producer of these compounds, the culture under study does not synthesize clavine alkaloids. The maximal roquefortine content was observed in the late logarithmic and early stationary growth phases while the maximal 3, 12-dihydroroquefortine content was obtained in the beginning of the stationary phase.

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1. N. E. Bekmakhanova and A. G. Kozlovsky, Mikrob. promyshlennost8, 39 (1974); in Russian.

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1. Institute of Biochemistry and Physiology of Microorganisms, USSR Academy of Sciences, USSR-142292, Pushchino, Moscow region, USSR

   A. G. Kozlovsky, T. F. Solovieva, T. A. Reshetilova & G. K. Skryabin

1. A. G. Kozlovsky
2. T. F. Solovieva
3. T. A. Reshetilova
4. G. K. Skryabin

Thanks are due to Drs V. M. Adanin and M. Yu. Nefedova for mass- and IR-spectra.

Kozlovsky, A.G., Solovieva, T.F., Reshetilova, T.A. et al. Biosynthesis of roquefortine and 3,12-dihydroroquefortine by the culture Penicillium farinosum. Experientia 37, 472–473 (1981). https://doi.org/10.1007/BF01986141

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• Published: 15 May 1981

• Issue Date: May 1981

• DOI: https://doi.org/10.1007/BF01986141

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