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Spontaneous neoplasms in aged sprague-dawley rats

Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid parafollicular cell adenomas (3.6%), fibromas and squamous cell papillomas of the skin and hepatocellular adenomas (2.0% in each), malignant lymphoma lymphocytic (1.9%), histiocytic sarcomas (1.4%), and adrenal cortical adenomas (1.2%). In female rats, the most common neoplasms were of mammary gland origin (31.3%: fibroadenoma 19.0%, adenocarcinomas 8.8%, and adenomas 3.5%) followed by thyroid parafollicular cell adenomas (2.9%), uterine endometrial stromal polyps (2.6%), adrenal cortical adenomas (1.9%), malignant lymphoma lymphocytic (1.6%), fibromas in the skin (1.3%), and pancreatic islet cell adenoma (1.1%). Metastases were observed from pheochromocytomas, hepatocellular carcinomas, nephroblastomas, renal pelvis transitional cell carcinoma, interstitial cell tumor and seminoma of the testes, Zymbal's gland adenocarcinomas, and mammary adenocarcinomas.

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• Chandra M, Frith CH (1992a) Spontaneous neoplasms in aged control Fischer 344 rats. Cancer Lett 62: 49–56

  PubMed  Google Scholar 

• Chandra M, Frith CH (1992b) Spontaneous neoplasms in B6C3F1 mice. Toxicol Lett 60: 91–98

  PubMed  Google Scholar 

• Chandra M, Frith CH (1992c) Spontaneous neoplasms in aged CD-1 mice. Toxicol Lett (in press)

• Chandra M, Riley MGI, Johnson DE (1991) Clear cell carcinoma in the trachea of a rat. Lab Anim Sci 41: 262–264

  PubMed  Google Scholar 

• Gregson RL, Lewis DJ, Abbott DP (1984) Spontaneous neoplasms of the laboratory rats. Vet Pathol 21: 292–299

  PubMed  Google Scholar 

• Gross L, Dreyfuss Y (1979) Spontaneous tumors in Sprague-Dawley and Long-Ewans rats in their F1 hybrids: carcinogenic effect of total-body X-irradiation. Proc Natl Acad Sci 76: 5910–5913

  PubMed  Google Scholar 

• Gould DH (1977) Mesotheliomas of the tunica vaginalis propria and peritonium in Fischer rats. Vet Pathol 14: 372–379

  PubMed  Google Scholar 

• Kaspareit-Rittinghausen J, Deerberg F, Rapp K, Wcislo A (1990) Mortality and tumour incidence of Han: SPRD rats. Z Versuchstierkd 33: 23–28

  PubMed  Google Scholar 

• Kinkle VHJ (1971) Spontantumoren bei Sprague-Dawley Ratten. Z Versuchstierk 13: 97–100

  Google Scholar 

• Krinke G, Naylor DC, Schmid S, Frohlich E, Schnider K (1985) The incidence of naturally-occurring primary brain tumors in the laboratory rat. J Comp Pathol 95: 175–192

  PubMed  Google Scholar 

• Lewis DJ (1987) Ovarian neoplasms in the Sprague-Dawley rats. Environ Health Perspect 73: 77–90

  PubMed  Google Scholar 

• Maekawa A, Onodera H, Tanigawa H, Furuta K, Matsuoka C, Kanno J, Ogiu T, Hayashi Y (1986) Spontaneous neoplastic and non-neoplastic lesions in aging Donryu rats. Jpn J Cancer Res 77: 882–890

  PubMed  Google Scholar 

• McComb DJ, Kovacs K, Beri J, Zak F (1984) Pituitary adenoma in old Sprague-Dawley rats: a histologic, ultrastructural, immunocytochemical study. N Natl Cancer Inst 73: 1143–1166

  Google Scholar 

• Prejean JD, Peckham JC, Casey AE, Griswold DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 33: 2768–2773

  PubMed  Google Scholar 

• Robertson JL, Garman RH, Fowler EH (1982) Spontaneous cardiac tumors in eight rats. Vet Pathol 19: 30–37

  PubMed  Google Scholar 

• Ross MH, Bras G (1965) Tumor incidence patterns and nutrition in the rat. J Nutr 87: 245–259

  PubMed  Google Scholar 

• Schardein JD, Fitzgerald, Kaump DH (1968) Spontaneous tumors in Holtzman-Source rats of various ages. Pathol Vet 5: 238–252

  PubMed  Google Scholar 

• Suzuki H, Mohr U, Kimmerle G (1979) Spontaneous endocrine tumors in Sprague-Dawley rats. J Cancer Res Clin Oncol 95: 187–196

  PubMed  Google Scholar 

• Turusov V, Mohr U (1990) Pathology of tumours in laboratory animals. Tumours of the rat. International Agency for Research on Cancer, Lyon, France

  Google Scholar 

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1. Wilbur G. Toxicology Laboratories, Medical Research Division, American Cyanamid Company, 10965, Pearl River, NY, USA

   Manik Chandra, Michael G. I. Riley & Dale E. Johnson

1. Manik Chandra
2. Michael G. I. Riley
3. Dale E. Johnson

Chandra, M., Riley, M.G.I. & Johnson, D.E. Spontaneous neoplasms in aged sprague-dawley rats. Arch Toxicol 66, 496–502 (1992). https://doi.org/10.1007/BF01970675

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• Received: 11 February 1992

• Accepted: 08 April 1992

• Issue Date: August 1992

• DOI: https://doi.org/10.1007/BF01970675

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