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Effect of sulfated and non-sulfated gastrin and octapeptide-cholecystokinin on cat gall bladder in vitro

This study demonstrates that for the isolated cat gall bladder a smaller molar dose of the sulfated form of OP-CCK and gastrin is required to produce contraction as compared to the respective non-sulfated forms. For OP the D₅₀ for the sulfated form versus the non-sulfated form was 1.94. For gastrin it was 1.10.

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1. J. R. Chowdhury

   Present address: Dept. of Medicine, Division of Gastroenterology, Albert Einstein College of Medicine, Bronx, N. Y., USA

1. Department of Physiology and Biophysics, State University of New York at Stony Brook, 11794, Stony Brook, N. Y., USA

   J. R. Chowdhury, J. M. Berkowitz, M. Praissman & J. W. Fara

2. Department Medicine, State University of New York at Stony Brook, 11794, Stony Brook, N. Y., USA

   J. R. Chowdhury, J. M. Berkowitz, M. Praissman & J. W. Fara

3. Division of Gastroenterology, Nassau Conty Medical Center, 11554, East Meadow, N. Y., USA

   J. R. Chowdhury, J. M. Berkowitz, M. Praissman & J. W. Fara

1. J. R. Chowdhury
2. J. M. Berkowitz
3. M. Praissman
4. J. W. Fara

This study was supported in part from NIH grant No. HL 15422 from the National Heart and Lung Institute.

Chowdhury, J.R., Berkowitz, J.M., Praissman, M. et al. Effect of sulfated and non-sulfated gastrin and octapeptide-cholecystokinin on cat gall bladder in vitro. Experientia 32, 1173–1175 (1976). https://doi.org/10.1007/BF01927609

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• Published: 01 September 1976

• Issue Date: September 1976

• DOI: https://doi.org/10.1007/BF01927609

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