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Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release

The dopamine D₃ preferring ligand R-(+)-7-OH-DPAT induced strong hypolocomotion in rats. Doses producing reduction of locomotion failed to affect dopamine release or synthesis rate. These data support the hypothesis that the dopamine D₃ receptor is a postsynaptic receptor with an inhibitory influence on rat locomotor activity.

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1. K. Svensson

   Present address: Department of Pharmacology, University of Göteborg, Göteborg, Sweden

1. Department of Pharmacology, University of Göteborg, Göteborg, Sweden

   A. Carlsson & N. Waters

1. K. Svensson
2. A. Carlsson
3. N. Waters

Svensson, K., Carlsson, A. & Waters, N. Locomotor inhibition by the D₃ ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release. J. Neural Transmission 95, 71–74 (1994). https://doi.org/10.1007/BF01283032

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• Received: 05 November 1993

• Accepted: 09 November 1993

• Issue Date: February 1994

• DOI: https://doi.org/10.1007/BF01283032

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