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Effect of lithium administration on rat brain 5-hydroxyindole levels in a possible animal model for mania

The effect of short term administration of lithium on the hyperactivity induced by a mixture of d-amphetamine (DEX) and chlordiazepoxide (CDZP) have been examined in the rat and an attempt made to relate this action to changes in brain concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA). The DEX-CDZP mixture caused a large increase in Y-maze entries (P<0.001). Lithium (2 or 4 mEq/kg) attenuated the increase in entries (P<0.001) and activity cage locomotion (P<0.01) without significantly affecting these parameters in saline-treated rats. However, the increased 5-HT concentration (P<0.05) found in the midbrain after the DEX-CDZP mixture was not modified by prior administration of lithium. In control rats lithium had no effect on the level of 5-HT in the cerebellum, cerebral cortex, midbrain or striatum. Levels of 5-hydroxyindoleacetic acid (5-HIAA) in all four brain regions were unaffected by both the DEX-CDZP mixture or pretreatment with lithium. The possible action of the DEX-CDZP mixture on central 5-HT systems and the suitability of the hyperactivity induced by the drug mixture as a model for mania is discussed.

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• Atterwill CK, Tordoff AFC (1982) Effects of repeated lithium administration on the subcellular distribution of 5-hydroxytryptamine in rat brain. Br J Pharmacol 76:413–421

  Google Scholar 

• Barnes JC, Costall B, Domeney AM, Naylor RJ (1986) Lithium and bupriopion antagonise the phasic changes in locomotor activity caused by dopamine infused into the rat nucleus accumbens. Psychopharmacology 89:311–316

  Google Scholar 

• Bliss EL, Ailion J (1970) The effect of lithium on brain neuroamines. Brain Res 24:305–310

  Google Scholar 

• Bunney WE, Garland BL (1983) Possible receptor effects of chronic lithium administration. Neuropharmacology 22:367–372

  Google Scholar 

• Byck R (1975) Drugs and the treatment of psychiatric disorders. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 5th edn. MacMillan, New York, pp 152–200

  Google Scholar 

• Coppen A, Noguera R, Baitey J, Burns BH, Swarin MS, Hare EH, Gardner R, Maggs R (1971) Prophylactic lithium in affective disorders. Lancet II:275–279

  Google Scholar 

• Cox C, Harrison-Read PE, Steinberg H, Tomkiewicz M (1971) Lithium attenuates “manic” activity in rats. Nature 232:336–338

  Google Scholar 

• Curzon G, Green AR (1970) Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain. Br J Pharmacol 39:653–655

  Google Scholar 

• Davies C, Sanger DJ, Steinberg H, Tomkiewicz M, U'Prichard DC (1974) Lithium and α-methyl-p-tyrosine prevent “manic” activity in rodents. Psychopharmacologica 36:263–274

  Google Scholar 

• Flemenbaum A (1975) Lithium and amphetamine hyperactivity in rats. Neuropsychobiology 1:325–334

  Google Scholar 

• Flemenbaum A (1977) Lithium inhibition of norepinephrine and dopamine receptors. Biol Psychiatry 12:563–572

  Google Scholar 

• Glowinski J, Iversen LL (1966) Regional studies of catecholamines in rat brain. 1. The disposition of (³H) norepinephrine, (³H) dopamine and (³H) dopa in various regions of the brain. J Neurochem 13:655–669

  Google Scholar 

• Grahame-Smith DG, Green AR (1974) The role of brain 5-hydroxytryptamine in the hyperactivity produced in rats by lithium and monoamine oxidase inhibition. Br J Pharmacol 52:19–26

  Google Scholar 

• Kelly PH, Seviour PW, Iversen SD (1975) Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens, septi and corpus striatum. Brain Res 94:507–522

  Google Scholar 

• Knapp S, Mandell AJ (1975) Effects of lithium chloride on parameters of biosynthetic capacity for 5-hydroxytryptamine in rat brain. J Pharm Exp Ther 193:812–823

  Google Scholar 

• Kuriyama K, Speken R (1970) Effect of lithium on content and uptake of norepinephrine and 5-hydroxytryptamine in mouse brain synaptosomes and mitochondria. Life Sci 9:1213–1220

  Google Scholar 

• Mendels J, Frazer A (1975) Reduced serotonergic activity in mania. Br J Psychiatry 126:241–248

  Google Scholar 

• Perez-Cruet J, Tagliamonte A, Tagliamonte P, Gessa GL (1971) Stimulation of serotonin synthesis by lithium. J Pharmacol Exp Ther 178:325–330

  Google Scholar 

• Prien RF, Caffey EM, Klett CJ (1972) Relationship between serum lithium level and clinical response in acute mania treated with lithium. Br J Psychiatry 120:409–414

  Google Scholar 

• Rushton R, Steinberg H (1966) Combined effects of chlordiazepoxide and dexamphetamine on activity of rats in an unfamiliar environment. Nature 211:1312–1313

  Google Scholar 

• Rushton R, Steinberg H, Tomkiewicz M (1973) Effects of chlordiazepoxide alone and in combination with amphetamine on animal and human behaviour. In: Garattini S, Mussini E, Randall LD (eds) Benzodiazepines. Raven, New York, pp 355–366

  Google Scholar 

• Sanger DJ, Steinberg H (1974) Inhibition of scopolamine-induced stimulation of Y-maze activity of α-methyl-p-tyrosine and by lithium. Eur J Pharmacol 28:344–349

  Google Scholar 

• Schildkraut JJ (1973) Neuropharmacology of the affective disorders. Annu Rev Pharmacol Toxicol 13:427–454

  Google Scholar 

• Schou M (1963) Normothymotics, “mood normalizers”: are lithium and the imipramine drugs specific for affective disorders? Br J Psychiatry 109:803–809

  Google Scholar 

• Schou M, Shaw DM (1973) Lithium in recurrent manic-depressive disorders. Practitioner 210:105–111

  Google Scholar 

• Steinberg H, Tomkiewicz M (1970) Animal behaviour models in psychopharmacology. In: Porter R, Birch J (eds) Chemical influences on behaviour. CIBA Foundation Study Group, No. 35. Churchill, London, pp 199–206

  Google Scholar 

• Van Praag HM (1978) Amine hypotheses of affective disorders. In: Iversen LL, Iversen SD, Snyder SM (eds) Handbook of psychopharmacology, vol 13. Plenum, New York, pp 187–297

  Google Scholar 

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1. A. L. Vale

   Present address: Department of Pharmacology and Clinical Pharmacology, The Medical School, Ninewells Hospital, DD1 9SY, DUNDEE, GB

1. Department of Pharmacology, School of Pharmacy, Brighton Polytechnic, BN2 4GL, Brighton, GB

   A. L. Vale & F. Ratcliffe

1. A. L. Vale
2. F. Ratcliffe

Vale, A.L., Ratcliffe, F. Effect of lithium administration on rat brain 5-hydroxyindole levels in a possible animal model for mania. Psychopharmacology 91, 352–355 (1987). https://doi.org/10.1007/BF00518190

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• Received: 10 October 1986

• Issue Date: September 1987

• DOI: https://doi.org/10.1007/BF00518190

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