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Antihypertensive effects of chronic 5-hydroxytryptamine (5-HT2) receptor blockade with ketanserin in the spontaneously hypertensive rat

The effects of chronic oral treatment with the 5-hydroxytryptamine (serotonin) receptor blocking agent ketanserin (17 mg/100 g dry food) on blood pressure, heart weight, peripheral vascular reactivity, baroreceptor sensitivity, central cardiovascular reactivity and central catecholamine turnover were investigated in the spontaneously hypertensive rat. Blood pressure measurements were performed in conscious rats 24 h after insertion of catheters. After 6 weeks treatment basal blood pressure was reduced (16%) compared to control rats (given identical food, except for ketanserin). Both heart weight and body weight were reduced (both to 93% of control values) leaving heart weight/body weight ratio unchanged. Pressor responses to phenylephrine and depressor responses to isoprenaline (after pretreatment with reserpine and atropin) were not different while the blood pressure increase to 5-hydroxytryptamine was inhibited, indicating that after 6 weeks treatment the blood pressure reduction is not directly related to α-adrenoceptor blockade. Cardiovascular response to stress (jet air), baroreceptor sensitivity (bradycardia to phenylephrine) and central catecholamine synthesis rates (accumulation of 5-hydroxytryptophan and dihydroxyphenylalanine after synthesis inhibition) were unchanged supporting earlier evidence that central mechanisms probably do not contribute to the hypotensive effects of ketanserin.

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1. Department of Pharmacology, University of Göteborg, Box 33031, S-400 33, Göteborg, Sweden

   Anders Pettersson, Bengt Persson, Matts Henning & Thomas Hedner

1. Anders Pettersson
2. Matts Henning
3. Thomas Hedner

Pettersson, A., Persson, B., Henning, M. et al. Antihypertensive effects of chronic 5-hydroxytryptamine (5-HT₂) receptor blockade with ketanserin in the spontaneously hypertensive rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 327, 43–47 (1984). https://doi.org/10.1007/BF00504990

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• Received: 02 December 1983

• Accepted: 20 March 1984

• Issue Date: March 1984

• DOI: https://doi.org/10.1007/BF00504990

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