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Discriminative stimulus properties of nicotine: Further evidence for mediation at a cholinergic receptor

Rats were trained to discriminate nicotine (0.4 mg/kg SC) from saline in a standard two-bar operant conditioning procedure with food reinforcement. The response to nicotine was dose-related and at the ED₅₀ of 0.14 mg/kg, plasma nicotine concentrations were similar to those reported previously for cigarette smokers who inhale. The nicotine analogues anabasine and cytisine increased nicotine-appropriate responding in a dose-related manner. Animals predominantly responded on the saline-associated lever when administered drugs from a range of pharmacological classes, even at doses that were sufficiently large to reduce the overall numbers of responses. The results confirm that the nicotine discriminative stimulus is highly specific. Previous work has shown anabasine and cytisine to be active at nicotinic-cholinergic binding sites in rat brain. The finding that there is some correlation between the behavioural effects of these compounds and their actions at the nicotine binding site may indicate that the nicotine cue is mediated throuth a cholinergic receptor.

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• Abood LG, Lowy K, Tometsko A, Booth H (1978) Electrophysiological, behavioural, and chemical evidence for a non-cholinergic stereospecific site for nicotine in rat brain. J Neurosci Res 3:327–333

  Google Scholar 

• Barlow RB, McLeod LJ (1969) Some studies on cytisine and its methylated derivatives. Br J Pharmacol 35:161–174

  Google Scholar 

• Barry H III (1974) Classification of drugs according to their discriminable effects in rats. Fed Proc 33:1814–1824

  Google Scholar 

• Chance WT, Murfin D, Krynock GM, Rosecrans JA (1977) A description of the nicotine stimulus and tests of its generalization to amphetamine. Psychopharmacology 55:19–26

  Google Scholar 

• Colpaert FC (1977) Drug-produced cues and states: Some theoretical and methodological inferences. In: Lal H (ed) Discriminative stimulus properties of drugs. Plenum, New York, pp 5–21

  Google Scholar 

• D'Mello GD, Stolerman IP (1977) Comparison of the discriminative stimulus properties of cocaine and amphetamine in rats. Br J Pharmacol 61:415–422

  Google Scholar 

• Feyerabend C, Russell MA (1980) Assay of nicotine in biological materials: sources of contamination and their elimination. J Pharm Pharmacol 32:178–181

  Google Scholar 

• Garcha HS, Giardini V, Pratt JA, Stolerman IP (1983) Anabasine and cytisine: nicotine-like behavioural effecs in a drug-discrimination procedure. Br J Pharmacol 79:272P

  Google Scholar 

• Garcha HS, Kumar R, Pratt JA, Stolerman IP (1982) Characteristics of the nicotine cue in rats. Br J Pharmacol 76:227P

  Google Scholar 

• Gilbert DG (1979) Paradoxical tranquilizing and emotion-reducing effects of nicotine. Psychol Bull 86:643–661

  Google Scholar 

• Giorguieff MF, Le Floc'h ML, Glowinski J, Besson MJ (1977) Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat. J Pharmacol Exp Ther 200:535–544

  Google Scholar 

• Guidotti A, Toffano G, Costa E (1978) An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain. Nature 275:553–555

  Google Scholar 

• Haefely W (1974) The effects of various “nicotine-like” agents in the cat superior cervical ganglion in situ. Naunyn-Schmiedeberg's Arch Pharmacol 281:93–117

  Google Scholar 

• Haefely W, Kulcsar A, Möhler H, Pieri L, Polc P, Schaffner R (1975) Possible involvement of GABA in the central actions of benzodiazepines. In: Costa E, Greengard P (eds) Advances in biochemical psychopharmacology, vol 14. Raven Press, New York, pp 131–151

  Google Scholar 

• Hirschhorn ID, Rosecrans JA (1974) Studies on the time course and the effect of cholinergic and adrenergic receptor blockers on the stimulus effects of nicotine. Psychopharmacology 40:109–120

  Google Scholar 

• Ho BT, Huang J-T (1975) Role of dopamine in d-amphetamine-induced discriminative responding. Pharmacol Biochem Behav 3:1085–1092

  Google Scholar 

• Meltzer LT, Rosecrans JA (1981) Discriminative stimulus properties of arecoline: A new approach for studying central muscarinic receptors. Psychopharmacology 75:383–387

  Google Scholar 

• Morrison CF, Stephenson JA (1969) Nicotine injections as the conditioned stimulus in discrimination learning. Psychopharmacologia 15:351–360

  Google Scholar 

• Pieri L, Schaffner R, Scherschlicht R, Polc P, Sepinwall J, Davidson A, Möhler H, Cumin R, Da Prada M, Burkard WP, Keller HH, Müller RK, Gerold M, Pieri M, Cook L, Haefely W (1981) Pharmacology of midazolam. Drug Res 31:2180–2201

  Google Scholar 

• Romano C (1981) Nicotine action on rat colon. J Pharmacol Exp Ther 217:828–833

  Google Scholar 

• Romano C, Goldstein A (1980) Stereospecific nicotine receptors on rat brain membranes. Science 210:647–650

  Google Scholar 

• Romano C, Goldstein A, Jewell NP (1981) Characterization of the receptor mediating the nicotine discriminative stimulus. Psychopharmacology 74:310–315

  Google Scholar 

• Rosecrans JA, Chance WT (1977) Cholinergic and non-cholinergic aspects of the discriminative stimulus properties of nicotine. In: Lal H (ed) Discriminative stimulus properties of drugs. Plenum, New York, pp 155–185

  Google Scholar 

• Rosecrans JA, Kallman MJ, Glennon R (1978) The nicotine cue: an overview. In: Colpaert FC, Rosecrans JA (eds) Stimulus properties of drugs: Ten years of progress. Elsevier-North Holland, Amsterdam, pp 69–81

  Google Scholar 

• Russell MAH, Jarvis M, Iyer R, Feyerabend C (1980) Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers. Br Med J 280:972–976

  Google Scholar 

• Schechter MD, Rosecrans JA (1972) Nicotine as a discriminative cue in rats: Inability of related drugs to produce a nicotine-like cueing effect. Psychopharmacologia 27:379–387

  Google Scholar 

• Schwab LS, Kritzer MF (1982) The effect of cholinergic antagonists on a central response to nicotine. Experientia 38:119–120

  Google Scholar 

• Sershen H, Reith MEA, Lajtha A, Gennaro J (1981) Non-cholinergic, saturable binding of (±)-[³H]nicotine to mouse brain. Journal of Receptor Research 2:1–15

  Google Scholar 

• Snedecor GW, Cochran WG (1967) Statistical methods, 6th edn. Iowa University Press, Iowa

  Google Scholar 

• Stolerman IP, D'Mello GD (1981) Role of training conditions in discrimination of central nervous stimulants by rats. Psychopharmacology 73:295–303

  Google Scholar 

• Stolerman IP, Pratt JA, Garcha HS (1982) Further analysis of the nicotine cue in rats. In: Drug discrimination: applications in CNS pharmacology. Elsevier, Amsterdam, pp 203–210

  Google Scholar 

• Turner DM (1975) Influence of route of administration on metabolism of [¹⁴C] nicotine in four species. Xenobiotica 5:553–561

  Google Scholar 

• White FJ, Appel JB, Kuhn DM (1979) Discriminative stimulus properties of quipazine: direct serotonergic mediation. Neuropharmacology 18:143–151

  Google Scholar 

• Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New York

  Google Scholar 

• Yamamoto I, Inoki R, Iwatsubo K (1968) Penetration of nicotine-¹⁴C into several rat tissues in vivo and in vitro. Toxicol Appl Pharmacol 12:560–567

  Google Scholar 

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1. V. Giardini

   Present address: Psychopharmacology Section, Istituto Superiore di Sanita, Rome, Italy

1. Departments of Pharmacology and Psychiatry, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK

   J. A. Pratt, I. P. Stolerman, H. S. Garcha & V. Giardini

2. Poisons Unit, New Cross Hospital, Avonley Road, SE14, London, UK

   C. Feyerabend

1. J. A. Pratt
2. I. P. Stolerman
3. H. S. Garcha
4. V. Giardini
5. C. Feyerabend

Pratt, J.A., Stolerman, I.P., Garcha, H.S. et al. Discriminative stimulus properties of nicotine: Further evidence for mediation at a cholinergic receptor. Psychopharmacology 81, 54–60 (1983). https://doi.org/10.1007/BF00439274

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• Received: 17 February 1983

• Issue Date: August 1983

• DOI: https://doi.org/10.1007/BF00439274

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