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A comparison of bupropion, dextroamphetamine, and placebo in mixed-substance abusers

The subjective, behavioral, and physiological effects of bupropion, a nontricyclic antidepressant, were compared with those of dextroamphetamine and placebo in a randomized double-blind crossover study. The volunteers who participated were multiple-drug abusers. Six acute drug treatments, three doses of bupropion (100, 200, 400 mg), two doses of dextroamphetamine (15, 30 mg), and placebo were administered orally at intervals of not less than 72 h. Results indicated that the subjective effects of amphetamine as measured by the Addiction Research Center Inventory (ARCI) differed markedly from bupropion and placebo. Bupropion, in contrast to amphetamine, had no peripheral sympathomimetic effects and did not reduce appetite or caloric intake.

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• Cooper BR, Hester TJ, Maxwell RA (1980) Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): Evidence for selective blockade of dopamine uptake in vivo. J Pharmacol Exp Ther 215:127–133

  Google Scholar 

• Fabre L, Brodie H, Garver O, Zung W (1983) A multicenter evaluation of bupropion versus placebo in hospitalized depressed patients. J Clin Psychiatry (in press)

• Fann WE, Schroeder DH, Mehta NB, Soroko FE, Maxwell RA (1978) Clinical trial of bupropion HCl in treatment of depression. Curr Ther Res 23:222–229

  Google Scholar 

• Garattini S, Samanin R (1978) Central mechanisms of anorectic drugs. Raven, New York

  Google Scholar 

• Griffith JD, Cavanaugh JH, Held J, Oates JA (1970) Experimental psychosis induced by the administration of d-amphetamine. In: Costa E, Garattini S (eds) International Symposium on Amphetamines and Related Compounds: Proceedings of the Mario Negri Institute for Pharmacological Research, Milan, Italy. Raven, New York, pp 897–904

  Google Scholar 

• Griffith JD, Nutt JG, Jasinski DR (1975) A comparison of fenfluramine and amphetamine in man. Clin Pharmacol Ther 18:563–570

  Google Scholar 

• Haertzen CA, Hill HE, Belleville RE (1963) Development of the Addiction Research Center Inventory (ARCI): Selection of items that are sensitive to the effects of various drugs. Psychopharmacologia 4:155–166

  Google Scholar 

• Hill HE, Haertzen CA, Wolbach AB, Miner EJ (1963) The Addiction Research Center Inventory: Standardization of scales which evaluate subjective effects of morphine, amphetamine, pentobarbital, alcohol, LSD-25, pyrahexyl, and chlorpromazine. Psychopharmacologia 4:167–183

  Google Scholar 

• Jasinski DR, Nutt JG, Griffith JD (1974) Effects of diethylpropion and d-amphetamine after subcutaneous and oral administration. Clin Pharmacol Ther 16:645–652

  Google Scholar 

• Jones CN, Howard JL, McBennett ST (1980) Stimulus properties of antidepressants in the rat. Psychopharmacology 67:111–118

  Google Scholar 

• Martin WR, Haertzen CA, Hewett BB (1978) Psychopathology and pathophysiology of narcotic addicts, alcoholics and drug abusers. In: Lipton MA, DiMascio A, Killian KF (eds) Psychopharmacology: A generation of progress. Raven, New York, pp 1591–1602

  Google Scholar 

• Martin WR, Sloan JW, Sapira JD, Jasinski DR (1971) Physiologic, subjective and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine and methylphenidate in man. Clin Pharmacol Ther 12:245–258

  Google Scholar 

• Maxwell RA, Mehta NB, Tucker WE, Schroeder DH, Stern WC (1981) Bupropion. In: Goldberg ME (ed) Pharmacological and biochemical properties of drug substances. American Pharmaceutical Association. Washington DC, pp 1–55

  Google Scholar 

• Peck AW, Bye CE, Clubley M, Henson T, Riddington C (1979) A comparison of bupropion hydrochloride with dexamphetamine and amitriptyline in healthy subjects. Br J Clin Pharmacol 7:469–478

  Google Scholar 

• Soroko FE, Mehta NB, Maxwell RA, Ferris RM, Schroeder DA (1977) Bupropion hydrochloride (±α-butylamino-3-chloropropinophenone HCl): A novel antidepressant agent. J Pharm Pharmacol 29:767–769

  Google Scholar 

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1. Burroughs Wellcome Company, 27709, Research Triangle Park, NC, USA

   Loren Miller

2. Department of Psychiatry, Baylor College of Medicine, 77030, Houston, TX, USA

   John Griffith

1. Loren Miller
2. John Griffith

Miller, L., Griffith, J. A comparison of bupropion, dextroamphetamine, and placebo in mixed-substance abusers. Psychopharmacology 80, 199–205 (1983). https://doi.org/10.1007/BF00436152

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• Received: 29 September 1982

• Accepted: 08 February 1983

• Issue Date: June 1983

• DOI: https://doi.org/10.1007/BF00436152

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