A RetroSearch Logo

Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Search Query:

Showing content from https://link.springer.com/doi/10.1007/BF00433008 below:

The differential effects of haloperidol and methamphetamine on time estimation in the rat

Abstract

Forty rats were trained to make a left lever response if a signal (white noise) was 2.5s and to make a right lever response if the signal was 6.3s. When seven intermediate signal durations, to which responses were not reinforced, were randomly interspersed the probability of a right-lever (‘long’) response increased as a function of signal duration. Methamphetamine shifted this psychometric function leftward and decreased its slope: haloperidol also decreased the slope but shifted the function rightward. A combination of haloperidol and methamphetamine led to a function similar to the saline control function. The leftward shift probably reflects an increase in the speed of an internal clock, and the rightward shift probably reflects a decrease in its speed. Since methamphetamine releases several catecholamines, including dopamine, and haloperidol blocks dopamine receptors, it is plausible that the horizontal location of the psychometric function (the speed of the clock) is related to the effective level of dopamine.

This is a preview of subscription content, log in via an institution to check access.

Access this article Subscribe and save

Springer+ Basic

€34.99 /Month

Subscribe now Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. References

Download references

Author information Author notes
  1. Andres V. Maricq

    Present address: Department of Physiology, School of Medicine, University of California at San Francisco, 94143, San Francisco, CA, USA

Authors and Affiliations
  1. Department of Psychology, Brown University, 02912, Providence, RI, USA

    Andres V. Maricq & Russell M. Church

Authors
  1. Andres V. Maricq
  2. Russell M. Church
About this article Cite this article

Maricq, A.V., Church, R.M. The differential effects of haloperidol and methamphetamine on time estimation in the rat. Psychopharmacology 79, 10–15 (1983). https://doi.org/10.1007/BF00433008

Download citation

Key words

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.4