Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://link.springer.com/doi/10.1007/BF00432565 below:

Nigral actions of GABA agonists are enhanced by chronic fluphenazine and differentiated by concomitant flurazepam

Unilateral intranigral administration of baclofen (50–200 ng), muscimol (2.5–20 ng), or THIP (50–400 ng) in the rat led to contralateral circling behavior of a qualitatively similar nature. The potency of all three GABA-mimetics was enhanced in animals which had received the depot neuroleptic fluphenazine decanoate (10 mg/kg SC) 7 days prior to their intranigral administration. Significant differences between the nigral actions of the drugs could be demonstrated by their altered activity in the presence of a benzodiazepine. Flurazepam (500 ng) enhanced the intranigral potency of THIP, but reduced that of intranigral baclofen. Muscimol-induced circling behavior was unaffected by concomitant flurazepam. The data provide evidence for a functional supersensitivity of GABA-sensitive nondopaminergic projections from the substantia nigra in response to chronic neuroleptic treatment and reveal differences between the precise sites or modes of action of baclofen, muscimol, and THIP within this structure.

This is a preview of subscription content, log in via an institution to check access.

Springer+ Basic

€34.99 /Month

• Get 10 units per month
• Download Article/Chapter or eBook
• 1 Unit = 1 Article or 1 Chapter
• Cancel anytime

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

• Allan RD, Evans RH, Johnston GAR (1980) γ-Aminobutyric acid agonists: An in vitro comparison between depression of spinal synaptic activity and depolarization of spinal root fibres in the rat. Br J Pharmacol 70:609–615

  Google Scholar 

• Andén NE, Stock G (1973) Inhibitory effect of gammahydroxybutyric acid on the dopamine cells in the substantia nigra. Naunyn Schmiedebergs Arch Pharmacol 279:89–92

  Google Scholar 

• Arnt J, Scheel-Krüger J (1979) GABAergic and glycinergic mechanisms within the substantia nigra: Pharmacological specificity of dopamine-independent contralateral turning behaviour and interactions with other neurotransmitters. Psychopharmacology 62:267–277

  Google Scholar 

• Braestrup C, Nielsen M, Krogsgaard-Larsen P, Falch E (1979) Partial agonists for brain GABA/benzodiazepine receptor complex. Nature 280:331–333

  Google Scholar 

• Clavier RM, Admadja S, Fibiger HC (1976) Nigrothalamic projections in the rat as demonstrated by orthograde and retrograde tracing techniques. Brain Res Bull 1:379–384

  Google Scholar 

• Enna SJ (1981) GABA receptors. Trends Pharmacol Sci 2:62–64

  Google Scholar 

• Enna SJ, Bennett JP, Bylund DB, Snyder SH, Bird ED, Iversen LL (1976) Alterations of brain neurotransmitters binding in Huntington's chorea. Brain Res 116:531–537

  Google Scholar 

• Gale K (1980) Chronic blockade of dopamine receptors by antischizophrenic drugs enhances GABA binding in substantia nigra. Nature 287:569–570

  Google Scholar 

• Gale K, Costa E, Toffano G, Hong JS, Guidotti A (1978) Evidence for a role of nigral γ-aminobutyric acid and substance P in the haloperidol-induced activation of striatal tyrosine hydroxylase. J Pharmacol Exp Ther 206:29–37

  Google Scholar 

• Graybiel AM (1978) Organisation of the nigro-tectal connection in an experimental tracer study in the cat. Brain Res 143:125–138

  Google Scholar 

• Hill DR, Bowery NG (1981) ³H-Baclofen and ³H-GABA bind to bicuculline-insensitive GABA-B sites in rat brain. Nature 290:149–152

  Google Scholar 

• James RA, Starr MS (1978) The role of GABA in the substantia nigra. Nature 275:229–230

  Google Scholar 

• König JFR, Klippel RA (1963) The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem. Williams and Wilkins, Baltimore

  Google Scholar 

• Kozlowski MR, Marshall JF (1980) Rotations induced by intra-nigral injections of GABA agonists and antagonists: Zone-specific effects. Pharmacol Biochem Behav 13:561–567

  Google Scholar 

• Lloyd KG, Shemen L, Hornykiewicz O (1977) Distribution of high affinity sodium-independent ³H-gamma-aminobutyric acid (³H-GABA) binding in the human brain: Alterations in Parkinson's disease. Brain Res 127:269–278

  Google Scholar 

• Marco E, Mao CC, Revueleta A, Peralta E, Costa E (1978) Turnover rates of γ-aminobutyric acid in substantia nigra, N. caudatus, globus pallidus and N. accumbens of rats injected with cataleptogenic and non-cataleptogenic antipsychotics. Neuropharmacology 17:589–596

  Google Scholar 

• Morelli M, Porceddu ML, Di Chiara G (1980) Lesions of substantia nigra by kainic acid: Effects on apomorphine-induced behaviour. Brain Res 191:67–78

  Google Scholar 

• Olianas MC, De Montis GM, Mulas G, Tagliamonte A (1978) The striatal dopaminergic function is mediated by the inhibition of a nigral, non-dopaminergic neuronal system via a strio-nigral GABAergic pathway. Eur J Pharmacol 49:233–241

  Google Scholar 

• Papadopoulos G, Huston JP (1980) Removal of the telencephalon spares turning induced by injection of GABA agonists and antagonists into the substantia nigra. Behav Brain Res 1:25–38

  Google Scholar 

• Pope SG, Dean P, Redgrave P (1980) Dissociation of d-amphetamine-induced locomotor activity and stereotyped behaviour by lesions of the superior colliculus. Psychopharmacology 70:297–302

  Google Scholar 

• Racagni G, Bruno F, Cattabeni F, Maggi A, Di Giulio AM, Parenti M, Groppetti A (1977) Functional interaction between rat substantia nigra and striatum: GABA and dopamine interrelation. Brain Res 134:353–358

  Google Scholar 

• Rinvik E, Grovofa I, Ottersen PO (1976) Demonstration of nigro-tectal and nigro-reticular projections in the cat by axonal transport of proteins. Brain Res 112:388–394

  Google Scholar 

• Scheel-Krüger J, Arnt J, Magelund G (1977) Behavioural stimulation induced by muscimol and other GABA agonists injected into the substantia nigra. Neurosci Lett 4:351–356

  Google Scholar 

• Waddington JL, Cross AJ (1978) Denervation supersensitivity in the striatonigral pathway. Nature 276:618–620

  Google Scholar 

• Waddington JL, Cross AJ (1979) Baclofen and muscimol: Behavioural and neurochemical sequelae of unilateral intranigral administration and effects on ³H-GABA receptor binding. Naunyn Schmiedebergs Arch Pharmacol 306:275–280

  Google Scholar 

• Wheeler SC, Roth RH (1980) Tolerance to fluphenazine and supersensitivity to apomorphine in central dopaminergic systems after chronic fluphenazine decanoate treatment. Naunyn Schmiedebergs Arch Pharmacol 312:151–159

  Google Scholar 

Download references

1. Wander Research Institute (a Sandoz Research Unit), Wander Ltd., PO Box 2747, CH-3001, Berne, Switzerland

   D. M. Coward

Coward, D.M. Nigral actions of GABA agonists are enhanced by chronic fluphenazine and differentiated by concomitant flurazepam. Psychopharmacology 76, 294–298 (1982). https://doi.org/10.1007/BF00432565

Download citation

• Received: 29 September 1981

• Accepted: 07 January 1982

• Issue Date: March 1982

• DOI: https://doi.org/10.1007/BF00432565

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.4