Mice implanted with stimulating electrodes in the lateral hypothalamus demonstrated reliable selfstimulation rates when given the opportunity to break a photobeam in a modified hole-board task. Selfstimulation rates were enhanced by low dosages of d-amphetamine but were depressed by high dosages. The dose-dependent effects of amphetamine could not be accounted for by changes in exploratory hole-board activity and were discussed in terms of an interaction between the rewarding properties of electrical brain stimulation and the reinforcing properties of amphetamine administration.
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Department of Psychology, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada
Larry Kokkinidis
Department of Psychology, University of Calgary, Calgary, Alberta, Canada
Robert M. Zacharko
Kokkinidis, L., Zacharko, R.M. Intracranial self-stimulation in mice using a modified hole-board task: Effects of d-amphetamine. Psychopharmacology 68, 169–171 (1980). https://doi.org/10.1007/BF00432136
Received: 16 July 1979
Accepted: 19 December 1979
Issue Date: May 1980
DOI: https://doi.org/10.1007/BF00432136
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