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Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25)

1. 1.

   The psychotomimetic potency of 13 congeners of LSD-25 has been approximately determined in man.

2. 2.

   With the exception of acetylation of the indole nitrogen, all the changes made in the LSD molecule reduced psychotomimetic potency. Bromination at carbon 2 caused the greatest inactivation.

3. 3.

   High potency as a serotonin antagonist in isolated smooth muscle preparations was not correlated with high potency as a psychotomimetic.

4. 4.

   The data do not support but do not disprove the “serotonin deficiency” hypothesis of the LSD psychosis.

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1. National Institute of Mental Health, Addiction Research Center, U. S. Public Health Service, Lexington, Kentucky

   Harris Isbell, E. J. Miner & C. R. Logan

1. Harris Isbell
2. E. J. Miner
3. C. R. Logan

Isbell, H., Miner, E.J. & Logan, C.R. Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25). Psychopharmacologia 1, 20–28 (1959). https://doi.org/10.1007/BF00408108

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• Received: 02 January 1959

• Issue Date: January 1959

• DOI: https://doi.org/10.1007/BF00408108

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