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Relation between the structure of certain methoxyphenylethylaminederivatives and the occurrence of a Hypokinetic Rigid Syndrome

The experiments with 9 phenylethylamine-derivatives on cats confirm that the occupation of the para-position in the phenol-ring by an OCH₃-group is essential to produce a Hypokinetic Rigid Syndrome (H.R.S.). Treating cats with molecular equivalent doses, the duration of this syndrome can be prolonged when OCH₃-groups are occupying, apart from the para-position, other places adjacent to the paraposition as well. A striking parallelism of mydriasis and salivation with the H.R.S., both in duration and intensity, was noted.

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1. Department of Pharmacology, University of Utrecht, Utrecht, The Netherlands

   A. M. Ernst

Ernst, A.M. Relation between the structure of certain methoxyphenylethylaminederivatives and the occurrence of a Hypokinetic Rigid Syndrome. Psychopharmacologia 7, 383–390 (1965). https://doi.org/10.1007/BF00402360

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• Received: 19 September 1964

• Issue Date: November 1965

• DOI: https://doi.org/10.1007/BF00402360

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