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Showing content from https://link.springer.com/doi/10.1007/BF00175206 below:

Effects of repeated administration of the monoamine oxidase inhibitor phenelzine on the discriminability of d-lysergic acid diethylamide (LSD) and 1-(m-trifluoromethylphenyl) piperazine (TFMPP)

Rats trained to discriminate d-lysergic acid diethylamide (LSD; 0.08 mg/kg) or 1-(m-trifluoromethylphenyl) piperazine (TFMPP; 0.8 mg/kg) were treated with the monoamine oxidase inhibitor (MAOI) phenelzine (10 mg/kg/day) for 7 days. After a 24 h “washout” period, they were challenged with the training drug (and dose) or saline, during extinction test sessions. Following 0.08 mg/kg LSD, LSD-trained rats responded primarily on the saline lever (29% drug-appropriate responding) while, after TFMPP (0.8 mg/kg), TFMPP-trained animals responded on the drug lever (75% drug-appropriate responding). These preliminary data suggest that, if serotonin receptors are involved in the behavioral effects of TFMPP, these receptors differ from those involved in the effects of LSD.

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• Cunningham KA, Appel JB (1984) Discriminative stimulus properties of trifluoromethylphenylpiperazine (TFMPP): Effects of serotonin agonists and antagonists. Soc Neurosci Abstr 10:218

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1. Kathryn A. Cunningham

   Present address: Department of Pharmacology, University of Texas Medical Branch, 77550, Galveston, TX, USA

1. Behavioral Pharmacology Laboratory, Department of Psychology, University of South Carolina, 29208, Columbia, SC, USA

   Kathryn A. Cunningham, Brenda A. Carroll & James B. Appel

1. Kathryn A. Cunningham
2. Brenda A. Carroll
3. James B. Appel

Cunningham, K.A., Carroll, B.A. & Appel, J.B. Effects of repeated administration of the monoamine oxidase inhibitor phenelzine on the discriminability of d-lysergic acid diethylamide (LSD) and 1-(m-trifluoromethylphenyl) piperazine (TFMPP). Psychopharmacology 89, 134–135 (1986). https://doi.org/10.1007/BF00175206

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• Received: 25 June 1985

• Revised: 01 November 1985

• Issue Date: May 1986

• DOI: https://doi.org/10.1007/BF00175206

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