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Showing content from https://link.springer.com/doi/10.1007/978-3-211-78207-1 below:

The Epothilones: An Outstanding Family of Anti-Tumor Agents: From Soil to the Clinic

Authors:

1. K.- H. Altmann
2. G. Höfle
3. R. Müller
4. J. Mulzer
5. K. Prantz

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Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

8. Back Matter

   Pages 239-260

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• Book Title: The Epothilones: An Outstanding Family of Anti-Tumor Agents

• Book Subtitle: From Soil to the Clinic

• Authors: K.- H. Altmann, G. Höfle, R. Müller, J. Mulzer, K. Prantz

• Series Title: Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products

• DOI: https://doi.org/10.1007/978-3-211-78207-1

• Publisher: Springer Vienna

• eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

• Copyright Information: Springer-Verlag Vienna 2009

• Hardcover ISBN: 978-3-211-78206-4Published: 22 December 2008

• Softcover ISBN: 978-3-211-99928-8Published: 19 October 2010

• eBook ISBN: 978-3-211-78207-1Published: 29 September 2009

• Series ISSN: 0071-7886

• Edition Number: 1

• Number of Pages: IX, 260

• Topics: Organic Chemistry, Medicinal Chemistry, Biotechnology, Industrial Chemistry/Chemical Engineering, Bioorganic Chemistry

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