Dermody TS, Parker JS, Sherry B. Orthoreoviruses. In: Knipe DM, Howley PM, eds. Fields Virology. Sixth Edition. Philadelphia: Lippincott Williams & Wilkins, In press.
Virgin HW, Tyler KL, Dermody TS. Reovirus. In: Nathanson N, ed. Viral Pathogenesis. New York: Lippincott-Raven, 1997:669–699.
Duncan R, Horne D, Cashdollar LW et al. Identification of conserved domains in the cell attachment proteins of the three serotypes of reovirus. Virology 1990; 174:399–409.
Nibert ML, Dermody TS, Fields BN. Structure of the reovirus cell-attachment protein: A model for the domain organization of σ1. J Virol 1990; 64:2976–2989.
Tyler KL, McPhee DA, Fields BN. Distinct pathways of viral spread in the host determined by reovirus S1 gene segment. Science 1986; 233:770–774.
Weiner HL, Powers ML, Fields BN. Absolute linkage of virulence and central nervous system tropism of reoviruses to viral hemagglutinin. J Infect Dis 1980; 141:609–616.
Weiner HL, Drayna D, Averill Jr DR et al. Molecular basis of reovirus virulence: Role of the S1 gene. Proc Natl Acad Sci USA 1977; 74:5744-5748.
Morrison LA, Sidman RL, Fields BN. Direct spread of reovirus from the intestinal lumen to the central nervous system through vagal autonomic nerve fibers. Proc Natl Acad Sci USA 1991; 88:3852–3856.
Tardieu M, Powers ML, Weiner HL. Age-dependent susceptibility to reovirus type 3 encephalitis: Role of viral and host factors. Ann Neurol 1983; 13:602–607.
Dichter MA, Weiner HL. Infection of neuronal cell cultures with reovirus mimics in vitro patterns of neurotropism. Ann Neurol 1984; 16:603–610.
Weiner HL, Ault KA, Fields BN. Interaction of reovirus with cell surface receptors. I. Murine and human lymphocytes have a receptor for the hemagglutinin of reovirus type 3. J Immunol 1980; 124:2143–2148.
Lee PW, Hayes EC, Joklik WK. Protein σ1 is thereovirus cell attachment protein. Virology 1981; 108:156–163.
Furlong DB, Nibert ML, Fields BN. Sigma 1 protein of mammalian reoviruses extends from the surfaces of viral particles. J Virol 1988; 62:246–256.
Fraser RDB, Furlong DB, Trus BL et al. Molecular structure of the cell-attachment protein of reovirus: Correlation of computer-processed electron micrographs with sequence-based predictions. J Virol 1990; 64:2990–3000.
Gentsch JR, Pacitti AF. Effect of neuraminidase treatment of cells and effect of soluble glycoproteins on type 3 reovirus attachment to murine L cells. J Virol 1985; 56:356–364.
Paul RW, Choi AH, Lee PWK. The α-anomeric form of sialic acid is the minimal receptor determinant recognized by reovirus. Virology 1989; 172:382–385.
Dermody TS, Nibert ML, Bassel-Duby R et al. Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains. J Virol 1990; 64:4842–4850.
Chappell JD, Gunn VL, Wetzel JD et al. Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigmal. J Virol 1997; 71:1834–1841.
Chappell JD, Duong JL, Wright BW et al. Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reoviruses. J Virol 2000; 74:8472–8479.
Barton ES, Forrest JC, Connolly JL et al. Junction adhesion molecule is a receptor for reovirus. Cell 2001; 104:441–451.
Martin-Padura I, Lostaglio S, Schneemann M et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 1998; 142:117–127.
Williams LA, Martin-Padura I, Dejana E et al. Identification and characterisation of human junctional adhesion molecule (JAM). Mol Immunol 1999; 36:1175–1188.
Liu Y, Nusrat A, Schnell FJ et al. Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci 2000; 113:2363–2374.
Dryden KA, Wang G, Yeager M et al. Early steps in reovirus infection are associated with dramatic changes in supramolecular structure and protein conformation: Analysis of virions and subviral particles by cryoelectron microscopy and image reconstruction. J Cell Biol 1993; 122:1023–1041.
Chappell JD, Prota A, Dermody TS et al. Crystal structure of reovirus attachment protein σ1 reveals evolutionary relationship to adenovirus fiber. EMBO J 2002; 21:1–11.
Reiter DM, Frierson JM, Halvorson EE et al. Crystal structure of reovirus attachment protein σ1 in complex with sialylated oligosaccharides. PLoS Pathog 2011; 7:e1002166.
van Raaij MJ, Mitraki A, Lavigne G et al. A triple β-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein. Nature 1999; 401:935–938.
Guardado CP, Fox GC, Hermo Parrado XL et al. Structure of the carboxy-terminal receptor-binding domain of avian reovirus fibre sigmaC. J Mol Biol 2005; 354:137–149.
Prota AE, Campbell JA, Schelling P et al. Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding. Proc Natl Acad Sci USA 2003; 100:5366–5371.
Stehle T, Dermody TS. Structural similarities in the cellular receptors used by adenovirus and reovirus. Viral Immunol 2004; 17:129–143.
Forrest JC, Campbell JA, Schelling P et al. Structure-function analysis of reovirus binding to junctional adhesion molecule 1. Implications for the mechanism of reovirus attachment. J Biol Chem 2003; 278:48434–48444.
Kirchner E, Guglielmi KM, Strauss H et al. Structure of reovirus al in complex with its receptor junctional adhesion molecule-A. PLoS Pathog 2008; 4:e1000235.
Bewley MC, Springer K, Zhang YB et al. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science 1999; 286:1579–1583.
van Raaij MJ, Chouin E, van der Zandt H et al. Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution. Structure 2000; 8:1147–1155.
Spear PG. Viral interactions with receptors in cell junctions and effects on junctional stability. Dev Cell 2002; 3:462–464.
Compton T. Receptors and immune sensors: The complex entry path of human cytomegalovirus. Trends Cell Biol 2004; 14:5–8.
Ugolini S, Mondor I, Sattentau QJ. HIV-1 attachment: Another look. Trends Microbiol 1999; 7:144–149.
Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease. Annu Rev Immunol 1999; 17:657–700.
Barton ES, Connolly JL, Forrest JC et al. Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening. J Biol Chem 2001; 276:2200–2211.
Maginnis MS, Forrest JC, Kopecky-Bromberg SA et al. β1 integrin mediates internalization of mammalian reovirus. J Virol 2006; 80:2760–2770.
Breun LA, Broering TJ, McCutcheon AM et al. Mammalian reovirus L2 gene and λ2 core spike protein sequences and whole-genome comparisons of reoviruses type 1 Lang, type 2 Jones, and type 3 Dearing. Virology 2001; 287:333–348.
Hynes RO. Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 1992; 69:11–25.
Hynes R. Integrins: Bidirectional, allosteric signaling machines. Cell 2002; 110:673–687.
Maginnis MS, Mainou BA, Derdowski AM et al. NPXY motifs in the β1 integrin cytoplasmic tail are required for functional reovirus entry. J Virol 2008; 82:3181–3191.
Sturzenbecker LJ, Nibert ML, Furlong DB et al. Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle. J Virol 1987; 61:2351–2361.
Borsa J, Morash BD, Sargent MD et al. Two modes of entry of reovirus particles into L cells. J Gen Virol 1979; 45:161–170.
Borsa J, Sargent MD, Lievaart PA et al. Reovirus: Evidence for a second step in the intracellular uncoating and transcriptase activation process. Virology 1981; 111:191–200.
Rubin DH, Weiner DB, Dworkin C et al. Receptor utilization by reovirus type 3: Distinct binding sites on thymoma and fibroblast cell lines result in differential compartmentalization of virions. Microb Pathog 1992; 12:351–365.
Ehrlich M, Boll W, Van Oijen A et al. Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell 2004; 118:591–605.
Georgi A, Mottola-Hartshorn C, Warner A et al. Detection of individual fluorescently labeled reovirions in living cells. Proc Natl Acad Sci USA 1990; 87:6579–6583.
Mainou BA, Dermody TS. Transport to late endosomes is required for efficient reovirus infection. J Virol 2012; 86:8346–8358.
Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science 1983; 219:987–988.
Maratos-Flier E, Goodman MJ, Murray AH et al. Ammonium inhibits processing and cytotoxicity of reovirus, a nonenveloped virus. J Clin Invest 1986; 78:617–625.
Maxfield FR. Weak bases and ionophores rapidly and reversibly raise the pH in endocytic vesicles in cultured mouse fibroblasts. J Cell Biol 1982; 95:676–681.
Ohkuma S, Poole B. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc Natl Acad Sci USA 1978; 75:3327–3331.
Barrett AJ, Kembhavi AA, Brown MA et al. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J 1982; 201:189–198.
Baer GS, Dermody TS. Mutations in reovirus outer-capsid protein σ3 selected during persistent infections of L cells confer resistance to protease inhibitor E64. J Virol 1997; 71:4921–4928.
Chandran K, Nibert ML. Protease cleavage of reovirus capsid protein μ1/μ1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle. J Virol 1998; 762:467–475.
Ebert DH, Wetzel JD, Brumbaugh DE et al. Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein σ3. J Virol 2001; 75:3197–3206.
Jané-Valbuena J, Nibert ML, Spencer SM et al. Reovirus virion-like particles obtained by recoating infectious subvirion particles with baculovirus-expressed σ3 protein: An approach for analyzing σ3 functions during virus entry. J Virol 1999; 73:2963–2973.
Bond JS, Butler PE. Intracellular proteases. Annu Rev Biochem 1987; 56:333–364.
Gal S, Gottesman MM. The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity. Biochem Biophys Res Commun 1986; 139:156–162.
Gottesman MM, Sobel ME. Tumor promoters and Kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA. Cell 1980; 19:449–455.
Kirschke H, Langner J, Wiederanders B et al. Cathepsin L. A new proteinase from rat-liver lysosomes. Eur J Biochem 1977; 74:293–301.
Ebert DH, Deussing J, Peters C et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem 2002; 277:24609–24617.
Riese RJ, Wolf PR, Bromme D et al. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity 1996; 4:357–366.
Golden JW, Bahe JA, Lucas WT et al. Cathepsin S supports acid-independent infection by some reoviruses. J Biol Chem 2004; 279:8547–8557.
Johnson EM, Wetzel JD, Doyle JD et al. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J Virol 2009; 83:9630–9640.
Nygaard RM, Golden JW, Schiff LA. Impact of host proteases on reovirus infection in the respiratory tract. J Virol 2012; 86:1238–1243.
Tosteson MT, Nibert ML, Fields BN. Ion channels induced in lipid bilayers by subvirion particles of the nonenveloped mammalian reoviruses. Proc Natl Acad Sci USA 1993; 90:10549–10552.
Lucia-Jandris P, Hooper JW, Fields BN. Reovirus M2 gene is associated with chromium release from mouse L cells. J Virol 1993; 67:5339–5345.
Hooper JW, Fields BN. Role of the μ1 protein in reovirus stability and capacity to cause chromium release from host cells. J Virol 1996; 70:459–467.
Olland AM, Jané-Valbuena J, Schiff LA et al. Structure of the reovirus outer capsid and dsRNA-binding protein σ3 at 1.8 Å resolution. EMBO J 2001; 20:979–989.
Nason E, Wetzel J, Mukherjee S et al. A monoclonal antibody specific for reovirus outer-capsid protein σ3 inhibits σ1-mediated hemagglutination by steric hindrance. J Virol 2001; 75:6625–6634.
Wetzel JD, Wilson GJ, Baer GS et al. Reovirus variants selected duringpersistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly. J Virol 1997; 71:1362–1369.
Clark KM, Wetzel JD, Bayley J et al. Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein σ3. J Virol 2006; 80:671–681.
Doyle JD, Danthi P, Kendall EA et al. Molecular determinants of proteolytic disassembly of the reovirus outer capsid. J Biol Chem2012; 287:8029–8038.
Nibert ML, Schiff LA, Fields BN. Mammalian reoviruses contain a myristoylated structural protein. J Virol 1991; 65:1960–1967.
Smith RE, Zweerink HJ, Joklik WK. Polypeptide components of virions, top component and cores of reovirus type 3. Virology 1969; 39:791–810.
Odegard AL, Chandran K, Zhang X et al. Putative autocleavage of outer capsid protein μ1, allowing release of myristoylated peptide μ1N during particle uncoating, is critical for cell entry by reovirus. J Virol 2004; 78:8732–8745.
Nibert ML, Odegard AL, Agosto MA et al. Putative autocleavage of reovirus μ1 protein in concert with outer-capsid disassembly and activation for membrane permeabilization. J Mol Biol 2005; 345:461–474.
Bodkin DK, Nibert ML, Fields BN. Proteolytic digestion of reovirus in the intestinal lumens of neonatal mice. J Virol 1989; 63:4676–4681.
Nibert ML, Fields BN. A carboxy-terminal fragment of protein μ1/μ1C is present in infectious subvirion particles of mammalian reoviruses and is proposedto have arole in penetration. J Virol 1992; 66:6408–6418.
Chandran K, Walker SB, Chen Y et al. In vitro recoating of reovirus cores with baculovirus-expressed outer-capsid proteins μ1 and μ3. J Virol 1999; 73:3941–3950.
Chandran K, Parker JS, Ehrlich M et al. The deltaregion of outer-capsid protein μ1 undergoes conformational change and release from reovirus particles during cell entry. J Virol 2003; 77:13361–13375.
Ivanovic T, Agosto MA, Zhang L et al. Peptides released from reovirus outer capsid form membrane pores that recruit virus particles. EMBO J 2008; 27:1289–1298.
Chandran K, Farsetta DL, Nibert ML. Strategy for nonenveloped virus entry: A hydrophobic conformer of the reovirus membrane penetration protein μ1 mediates membrane disruption. J Virol 2002; 76:9920–9933.
Liemann S, Chandran K, Baker TS et al. Structure of the reovirus membrane-penetration protein, μ1, in a complex with its protector protein, σ3. Cell 2002; 108:283–295.
Tyler KL, Squier MK, Rodgers SE et al. Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein μ1. J Virol 1995; 69:6972–6979.
Rodgers SE, Barton ES, Oberhaus SM et al. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J Virol 1997; 71:2540–2546.
Connolly JL, Rodgers SE, Clarke P et al. Reovirus-induced apoptosis requires activation of transcription factor NF-κB. J Virol 2000; 74:2981–2989.
Oberhaus SM, Smith RL, Clayton GH et al. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol 1997; 71:2100–2106.
O’Donnell SM, Hansberger MW, Connolly JL et al. Organ-specific roles for transcription factor NF-κB in reovirus-induced apoptosis and disease. J Clin Invest 2005; 115:2341–2350.
DeBiasi R, Edelstein C, Sherry B et al. Calpain inhibition protects against virus-induced apoptotic myocardial injury. J Virol 2001; 75:351–361.
DeBiasi RL, Robinson BA, Sherry B et al. Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo. J Virol 2004; 78:11040–11050.
Connolly JL, Barton ES, Dermody TS. Reovirus binding to cell surface sialic acid potentiates virus-induced apoptosis. J Virol 2001; 75:4029–4039.
Tyler KL, Squier MKT, Brown AL et al. Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: Role of the S1 and M2 genes. J Virol 1996; 70:7984–7991.
Ernst H, Shatkin AJ. Reovirus hemagglutinin mRNA codes for two polypeptides in overlapping reading frames. Proc Natl Acad Sci USA 1985; 82:48–52.
Jacobs BL, Atwater JA, Munemitsu SM et al. Biosynthesis of reovirus-specified polypeptides. The S1 mRNA synthesized in vivo is structurally and functionally indistinguishable from in vitro-synthesized S1 mRNA and encodes two polypeptides, σ1a and σ1bNS. Virology 1985; 147:9–18.
Sarkar G, Pelletier J, Bassel-Duby R et al. Identification of a new polypeptide coded by reovirus gene S1. J Virol 1985; 54:720–725.
Rodgers SE, Connolly JL, Chappell JD et al. Reovirus growth in cell culture does not require the full complement of viral proteins: Identification of a σ1s-null mutant. J Virol 1998; 72:8597–8604.
Hoyt CC, Richardson-Burns SM, Goody RJ et al. Nonstructural protein sigmals is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system. J Virol 2005; 79:2743–2753.
Boehme KW, Guglielmi KM, Dermody TS. Reovirus nonstructural protein σ1s is requiredfor establishment of viremia and systemic dissemination. Proc Natl Acad Sci USA 2009; 106:19986–19991.
Boehme KW, Frierson JM, Konopka JL et al. The reovirus als protein is a determinant of hematogenous but not neural viral dissemination in mice. J Virol 2011; 85:11781–11790.
Campbell JA, Shelling P, Wetzel JD et al. Junctional adhesion molecule-A serves as areceptor for prototype and field-isolate strains of mammalian reovirus. J Virol 2005; 79:7967–7978.
Dermody TS, Nibert ML, Bassel-Duby R et al. A sigma 1 region important for hemagglutination by serotype 3 reovirus strains. J Virol 1990; 64:5173–5176.
Connolly JL, Dermody TS. Virion disassembly is required for apoptosis induced by reovirus. J Virol 2002; 76:1632–1641.
Danthi P, Hansberger MW, Campbell JA et al. JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis. J Virol 2006; 80:1261–1270.
Hazelton PR, Coombs KM. The reovirus mutanttsA279 has temperature-sensitive lesions in the M2 and L2 genes: The M2 gene is associated with decreased viral protein production and blockade in transmembrane transport. Virology 1995; 207:46–58.
Danthi P, Kobayashi T, Holm GH et al. Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. J Virol 2008; 82:161–172.
Danthi P, Kobayashi T, Coffey CM et al. Independent regulation of reovirus membrane penetration and apoptosis by the μ1 f domain. PLoS Pathog 2008; 4:e1000248.
Clarke P, Meintzer SM, Moffitt LA et al. Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem 2003; 278:18092–18100.
Beg A, Finco T, Nantermet P et al. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα: A mechanism for NF-κB activation. Mol Cell Biol 1993; 13:3301–3310.
Cahir McFarland ED, Izumi KM, Mosialos G. Epstein-barr virus transformation: Involvement of latent membrane protein 1-mediated activation of NF-kappaB. Oncogene 1999; 18:6959–6964.
McKinsey TA, Brockman JA, Scherer DC et al. Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: A potential mechanism for constitutive induction of NF-kappaB. Mol Cell Biol 1996; 16:2083–2090.
Abbadie C, Kabrun N, Bouali F et al. High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro. Cell 1993; 75:899–912.
Grimm S, Bauer MKA, Baeuerle PA et al. Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis. J Cell Biol 1996; 134:13–23.
Jung M, Zhang Y, Lee S et al. Correction of radiation sensitivity in ataxiatelangiectasia cells by atruncated IκB-α. Science 1995; 268:1619–1621.
Beg A, Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 1996; 274:782–784.
Liu ZG, Hsu H, Goeddel D et al. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 1996; 87:565–576.
Van Antwerp D, Martin S, Kafri T et al. Suppression of TNF-α-induced apoptosis by NF-κB. Science 1996; 274:787–789.
Clarke P, Meintzer SM, Widmann C et al. Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun. J Virol 2001; 75:11275–11283.
Clarke P, Meintzer SM, Wang Y et al. JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells. J Virol2004; 78:13132–13138.
Norman KL, Hirasawa K, Yang AD et al. Reovirus oncolysis: The Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection. Proc Natl Acad Sci USA 2004; 101:11099–11104.
Meusel TR, Imani F. Viral induction of inflammatory cytokines in human epithelial cells follows a p38 mitogen-activated protein kinase-dependent but NF-kappa B-independent pathway. J Immunol 2003; 171:3768–3774.
Duncan MR, Stanish SM, Cox DC. Differential sensitivity of normal and transformed human cells to reovirus infection. J Virol 1978; 28:444–449.
Strong JE, Coffey MC, Tang D et al. The molecular basis of viral oncolysis: Usurpation of the Ras signaling pathway by reovirus. EMBO J 1998; 17:3351–3362.
Strong JE, Lee PW. The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection. J Virol 1996; 70:612–616.
Coffey MC, Strong JE, Forsyth PA et al. Reovirus therapy of tumors with activated Ras pathway. Science 1998; 282:1332–1334.
Mundschau LJ, Faller DV. Oncogenic ras induces an inhibitor of double-stranded RNA-dependent eukaryotic initiation factor 2 alpha-kinase activation. J Biol Chem 1992; 267:23092–23098.
Williams ME, Cox DC, Stevenson JR. Rejection of reovirus-treated L1210 leukemia cells by mice. Cancer Immunol Immunother 1986; 23:87–92.
Wilcox ME, Yang W, Senger D et al. Reovirus as an oncolytic agent against experimental human malignant gliomas. J Natl Cancer Inst 2001; 93:903–912.
Norman KL, Coffey MC, Hirasawa K et al. Reovirus oncolysis of human breast cancer. Hum Gene Ther 2002; 13:641–652.
Holm GH, Zurney J, Tumilasci V et al. Retinoic acid-inducible gene-I and interferon-β promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatoryfactor-3. J Biol Chem 2007; 282:21953–21961.
Kato H, Takeuchi O, Mikamo-Satoh E et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med 2008; 205:1601–1610
Loo YM, Fornek J, Crochet N et al. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol 2008; 82:335–345.
Knowlton JJ, Dermody TS, Holm GH. Apoptosis induced by mammalian reovirus is interferon-β-independent and enhanced by IRF-3-and NF-κB-dependent expression of Noxa. J. Virol 2012; 86:1650–1660.
DeBiasi RL, Clarke P, Meintzer SM et al. Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis. J Virol 2003; 77:8934–8947.
O’Donnell SM, Holm GH, Pierce JM et al. Identification of an NF-κB-dependent gene network in cells infected by mammalian reovirus. J Virol 2006; 80:1077–1086.
Smith JA, Schmechel SC, Raghavan A et al. Reovirus induces and benefits from an integrated cellular stress response. J Virol 2006; 80:2019–2033.
Webster GA, Perkins ND. Transcriptional cross talk between NF-κ B and p53. Mol Cell Biol 1999; 19:3485–3495.
Dreyfus D, Nagasawa M, Gelfand E et al. Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors. BMC Immunol 2005; 6:12.
Li Z, Niu J, Uwagawa T et al. Function of polo-like kinase 3 in NF-κB-mediated proapoptotic response. J Biol Chem 2005; 280:16843–16850.
Huang YH, Wu JY, Zhang Y et al. Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-kappaB/rel complexes. Oncogene 2002; 21:6819–6828.
Liu CY, Schröder M, Kaufman RJ. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem 2000; 275:24881–24885.
Harding HP, Zhang Y, Bertolotti A et al. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000; 5:897–904.
Sen GC. Viruses and interferons. Annu Rev Microbiol 2001; 55:255–281.
Stark GR, Kerr IM, Williams BR et al. How cells respond to interferons. Annu Rev Biochem 1998; 67:227–264.
Kunzi MS, Pitha PM. Interferon targeted genes in host defense. Autoimmunity 2003; 36:457–461.
Tanaka N, Sato M, Lamphier MS et al. Type I interferons are essential mediators of apoptotic death in virally infected cells. Genes Cells 1998; 3:29–37.
Bingle CD, Craig RW, Swales BM et al. Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death. J Biol Chem 2000; 275:22136–22146.
Gurumurthy S, Goswami A, Vasudevan KM et al. Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. Mol Cell Biol 2005; 25:1146–1161.
Imazu T, Shimizu S, Tagami S et al. Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene 1999; 18:4523–4529.
Tan KO, Tan KML, Chan SL et al. MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with bax through its Bcl-2 homology domains. J Biol Chem 2001; 276:2802–2807.
Clarke P, Meintzer SM, Gibson S et al. Reovirus-induced apoptosis is mediated by TRAIL. J Virol 2000; 74:8135–8139.
Torii S, Egan DA, Evans RA et al. Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs). EMBO J 1999; 18:6037–6049.
Takahashi Y, Lallemand-Breitenbach V, Zhu J et al. PML nuclear bodies and apoptosis. Oncogene 2004; 23:2819–2824.
Richardson-Burns SM, Kominsky DJ, Tyler KL. Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol 2002; 8:365–380.
Blatt NB, Glick GD. Signaling pathways and effector mechanisms preprogrammed cell death. Bioorg Med Chem 2001; 9:1371–1384.
Kominsky DJ, Bickel RJ, Tyler KL. Reovirus-induced apoptosis requires both death receptor-and mitochondrial-mediated caspase-dependent pathways of cell death. Cell Death Differ 2002; 9:926–933.
Wajant H, Johannes FJ, Haas E et al. Dominant-negative FADD inhibits TNFR60-, Fas/Apol-and TRAIL-R/Apo2-mediated cell death but not gene induction. Curr Biol 1998; 8:113–116.
Clarke P, Debiasi RL, Meintzer SM et al. Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis. Apoptosis 2005; 10:513–524.
Chawla-Sarkar M, Lindner DJ, Liu YF et al. Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 2003; 8:237–249.
Shigeno M, Nakao K, Ichikawa T et al. Interferon-alphasensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation. Oncogene 2003; 22:1653–1662.
Li P, Nijhawan D, Budhardjo I et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91:479–489.
Verhagen AM, Ekert PG, Pakusch M et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000; 102:43–53.
Du C, Fang M, Li Y et al. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000; 102:33–42.
Joza N, Susin SA, Daugas E et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 2001; 410:549–554.
Li H, Zhu H, Xu CJ et al. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94:491–501.
Kominsky DJ, Bickel RJ, Tyler KL. Reovirus-induced apoptosis requires mitochondrial release of Smac/DIABLO and involves reduction of cellular inhibitor of apoptosis protein levels. J Virol 2002; 76:11414–11424.
Danthi P, Pruijssers AJ, Berger AK et al. Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog 2010; 6:e1000980.
Luo X, Budihardjo I, Zou H et al. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998; 94:481–490.
Richardson-Burns SM, Tyler KL. Regional differences in viral growth and central nervous system injury correlate with apoptosis. J Virol 2004; 78:5466–5475.
Richardson-Burns SM, Tyler KL. Minocycline delays disease onset and mortality in reovirus encephalitis. Exp Neurol 2005; 192:331–339.
Sherry B, Torres J, Blum MA. Reovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins. J Virol 1998; 72:1314–1323.
Azzam-Smoak K, Noah DL, Stewart MJ et al. Interferon regulatory factor-1, interferon-beta, and reovirus-induced myocarditis. Virology 2002; 298:20–29.
Stewart MJ, Blum MA, Sherry B. PKR’s protective role in viral myocarditis. Virology 2003; 314:92–100.
Noah DL, Blum MA, Sherry B. Interferon regulatory factor 3 is required for viral induction of beta interferon in primary cardiac myocyte cultures. J Virol 1999; 73:10208–10213.
Bazzoni G, Martinez-Estrada OM, Orsenigo F et al. Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. J Biol Chem 2000; 275:20520–20526.
Ebnet K, Schulz CU, Meyer Zu Brickwedde MK et al. Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. J Biol Chem 2000; 275:27979–27988.
Pfaff M, Liu S, Erle DJ et al. Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. J Biol Chem 1998; 273:6104–6109.
Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. J Cell Biol 1990; 111:721–729.
Schaller MD, Otey CA, Hildebrand JD et al. Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol 1995; 130:1181–1187.
Reszka AA, Hayashi Y, Horwitz AF. Identification of amino acid sequences in the integrinbeta 1 cytoplasmic domain implicated in cytoskeletal association. J Cell Biol 1992; 117:1321–1330.
Chen WJ, Goldstein JL, Brown MS. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J Biol Chem 1990; 265:3116–3123.
Deiss LP, Galinka H, Berissi H et al. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J 1996; 15:3861–3870.
Guicciardi ME, Deussing J, Miyoshi H et al. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 2000; 106:1127–1137.
Roberg K. Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy. Lab Invest 2001; 81:149–158.
Stoka V, Turk B, Schendel SL et al. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem 2001; 276:3149–3157.
Coffey CM, Sheh A, Kim IS et al. Reovirus outer capsid protein μ1 induces apoptosis and associates with lipid droplets, endoplasmic reticulum, and mitochondria. J. Virol. 80:8422–38, 2006.
Kim JW, Lyi SM, Parrish CR, Parker JS. A proapoptotic peptide derived from reovirus outer capsid protein μ1 has membrane-destabilizing activity. J Virol 2011; 85:1507–16.
Wisniewski ML, Werner BG, Horn LG et al. Reovirus infection or ectopic expression of outer capsid protein μ1 induces apoptosis independently of the cellular proapoptotic proteins Bax and Bak. J Virol 2011; 85:296–304.
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