Reparative surgery of the aortic root functional unit (ARFU) allows for a better preservation of the functionality of the native structure compared to prosthesis implantation. Post-operative results are satisfactory, whereas mid- and long-term results are challenging, for example in terms of cusps prolapse recurrence. At the Cardiothoracic Surgery Unit of the Sacco Hospital, a new surgical technique aimed at the stabilization in time of the results of standard ARFU repair operations has been applied. This technique, inspired by the mitral neo-chordae (NC) implantation, consists of implanting an e-PTFE suture thread between the prolapsed cusp and the sinotubular junction. Aim of this study was to assess the influence of NC implantation on the ARFU functioning by evaluating with an owned pulsatile in vitro apparatus the force magnitude acting on the NC and the dynamic behavior of porcine ARFUs treated according to the operating-room procedures. The maximum recorded values of the mean and peak diastolic forces were 0.064 and 0.186 N, respectively, and were linearly dependent upon the mean diastolic pressure across the valve. In addition, the measurements of the opening–closing times and valve leakage volumes, performed at pre- and post-surgeries, yielded that the valve functionality was not significantly influenced by NC implantation.
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This study was funded by the Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy. The authors gratefully thank Dr. Paolo D’Alesio and Emiliano Votta, PhD, for their technical supports.
Conflict of interest statementNone.
Author information Authors and AffiliationsDepartment of Bioengineering, Politecnico di Milano, via Golgi 39, 20133, Milan, Italy
R. Vismara, M. Cervo, A. Redaelli & G. B. Fiore
FoRCardioLab, Fondazione per la Ricerca in Cardiochirurgia ONLUS, Milan, Italy
R. Vismara, C. Antona, A. Mangini, M. Cervo, M. Contino, E. Bosisio, A. Redaelli & G. B. Fiore
Cardiac Surgery Unit, H.L. Sacco, Università di Milano, Milan, Italy
C. Antona, A. Mangini, M. Contino & E. Bosisio
Correspondence to R. Vismara.
Additional informationAssociate Editor Stefan Jockenhoevel oversaw the review of this article.
About this article Cite this articleVismara, R., Antona, C., Mangini, A. et al. In Vitro Study of Aortic Valves Treated with Neo-Chordae Grafts: Hydrodynamics and Tensile Force Measurements. Ann Biomed Eng 39, 1024–1031 (2011). https://doi.org/10.1007/s10439-010-0235-8
Received: 01 October 2010
Accepted: 18 December 2010
Published: 04 January 2011
Issue Date: March 2011
DOI: https://doi.org/10.1007/s10439-010-0235-8
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