Effects of GBR 12909 on exploratory behavior in C57BL/6J mice in the mouse BPM. Mice were administered various doses of the selective DAT inhibitor GBR 12909 prior to the assessment of their exploration in the mouse BPM. Exploration was measured in the BPM for activity levels—transitions (a), exploration—holepoking (b) and rearing (c), as well as locomotor patterns—spatial d (d). GBR 12909 increased activity at the highest (16 and 28.5 mg/kg) doses tested (a). The effects of GBR 12909 on exploration differed by dose and measure—the highest dose lowered holepoking (b) while the second highest dose increased rearing (c). Data presented as mean ± SEM. *p < 0.05 when compared to vehicle administered control mice
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