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Showing content from https://learn.microsoft.com/en-us/azure/api-management/api-management-howto-deploy-multi-region below:

Deploy an Azure API Management Instance to Multiple Azure Regions - Azure API Management

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Azure API Management supports multi-region deployment, which enables API publishers to add regional API gateways to an existing API Management instance in one or more supported Azure regions. Multi-region deployment helps reduce request latency perceived by geographically distributed API consumers and improves service availability if one region goes offline.

When adding a region, you configure:

Important

The feature to enable storing customer data in a single region is currently only available in the Southeast Asia Region (Singapore) of the Asia Pacific Geo. For all other regions, customer data is stored in Geo.

Important

Changes to your API Management service's infrastructure (such as configuring custom domains, adding CA certificates, scaling, virtual network configuration, availability zone changes, and region additions) can take 15 minutes or longer to complete, depending on the service tier and the size of the deployment. Expect longer times for an instance with a greater number of scale units or multi-region configuration. Rolling changes to API Management are executed carefully to preserve capacity and availability.

While the service is updating, other service infrastructure changes can't be made. However, you can configure APIs, products, policies, and user settings. The service will not experience gateway downtime, and API Management will continue to service API requests without interruption (except in the Developer tier).

About multi-region deployment Prerequisites Deploy API Management service to an additional region
  1. In the Azure portal, navigate to your API Management service and select Locations from the left menu.
  2. Select + Add in the top bar.
  3. Select the added location from the dropdown list.
  4. Select the number of scale Units in the location.
  5. If the region supports Availability zones, leave the Automatic setting (recommended), or optionally select one or more zones. If you select specific zones, the number of units that you select must distribute evenly across the availability zones. For example, if you select three units, you must select three zones so that each zone hosts one unit.
  6. If the API Management instance is deployed in a virtual network, configure virtual network settings in the location, including virtual network, subnet, and public IP address.
  7. Select Add to confirm.
  8. Repeat this process until you configure all locations.
  9. Select Save in the top bar to start the deployment process.
Remove an API Management service region
  1. In the Azure portal, navigate to your API Management service and select Locations from the left menu.
  2. For the location you would like to remove, select the context menu using the ... button at the right end of the table. Select Delete.
  3. Confirm the deletion and select Save to apply the changes.
Route API calls to regional backend services

By default, each API routes requests to a single backend service URL. Even if you configure API Management gateways in various regions, the API gateway still forwards requests to the same backend service, which is deployed in only one region. In this case, improved performance comes only from responses cached within API Management in a region specific to the request. Contacting the backend across the globe might still cause high latency.

To take advantage of geographical distribution of your system, you should deploy backend services in the same regions as API Management instances. Then, by using policies and the @(context.Deployment.Region) property, you can route the traffic to local instances of your backend.

  1. Go to your API Management instance and select APIs from the left menu.

  2. Select your desired API.

  3. On the Design tab, in the Inbound processing section, select Code editor.

  4. Use the set-backend combined with conditional choose policies to construct a proper routing policy in the <inbound> </inbound> section of the file.

    For example, the following XML file would work for West US and East Asia regions:

    <policies>
        <inbound>
            <base />
            <choose>
                <when condition="@("West US".Equals(context.Deployment.Region, StringComparison.OrdinalIgnoreCase))">
                    <set-backend-service base-url="http://contoso-backend-us.com/" />
                </when>
                <when condition="@("East Asia".Equals(context.Deployment.Region, StringComparison.OrdinalIgnoreCase))">
                    <set-backend-service base-url="http://contoso-backend-asia.com/" />
                </when>
                <otherwise>
                    <set-backend-service base-url="http://contoso-backend-other.com/" />
                </otherwise>
            </choose>
        </inbound>
        <backend>
            <base />
        </backend>
        <outbound>
            <base />
        </outbound>
        <on-error>
            <base />
        </on-error>
    </policies>
    
Use Traffic Manager for routing to regional backends

You can also front your backend services with Azure Traffic Manager, direct the API calls to the Traffic Manager, and let it resolve the routing automatically.

Use custom routing to API Management regional gateways

API Management routes the requests to a regional gateway based on the lowest latency. Although it isn't possible to override this setting in API Management, you can use your own Traffic Manager with custom routing rules.

  1. Create your own Traffic Manager.
  2. If you use a custom domain, use it with Traffic Manager instead of the API Management service.
  3. Configure the API Management regional endpoints in Traffic Manager. The regional endpoints follow the URL pattern of https://<service-name>-<region>-01.regional.azure-api.net, for example https://contoso-westus2-01.regional.azure-api.net.
  4. Configure the API Management regional status endpoints in Traffic Manager. The regional status endpoints follow the URL pattern of https://<service-name>-<region>-01.regional.azure-api.net/status-0123456789abcdef, for example https://contoso-westus2-01.regional.azure-api.net/status-0123456789abcdef.
  5. Specify the routing method of the Traffic Manager.
Disable routing to a regional gateway

Under some conditions, you might need to temporarily disable routing to one of the regional gateways. For example:

To disable routing to a regional gateway in your API Management instance, update the gateway's disableGateway property value to true. You can set the value by using the Create or update service REST API, the az apim update command in the Azure CLI, the set-azapimanagement Azure PowerShell cmdlet, or other Azure tools.

Note

You can only disable routing to a regional gateway when you use default routing in API Management, not a custom routing solution.

To disable a regional gateway by using the Azure CLI:

  1. Use the az apim show command to show the locations, gateway status, and regional URLs configured for the API Management instance.

    az apim show --name contoso --resource-group apim-hello-world-resource \
        --query "additionalLocations[].{Location:location,Disabled:disableGateway,Url:gatewayRegionalUrl}" \
        --output table
    

    Example output:

    Location    Disabled    Url
    ----------  ----------  ------------------------------------------------------------
    West US 2   True        https://contoso-westus2-01.regional.azure-api.net
    West Europe True        https://contoso-westeurope-01.regional.azure-api.net
    
  2. Use the az apim update command to disable the gateway in an available location, such as West US 2.

    az apim update --name contoso --resource-group apim-hello-world-resource \
    --set additionalLocations[location="West US 2"].disableGateway=true
    

    The update might take a few minutes.

  3. Verify that traffic directed to the regional gateway URL is redirected to another region.

To restore routing to the regional gateway, set the value of disableGateway to false.

Virtual networking

This section provides considerations for multi-region deployments when the API Management instance is injected in a virtual network.

Important

When you configure your API Management instance to use internal virtual network mode, each regional gateway must also have outbound connectivity on port 1433 to the Azure SQL database configured for your API Management instance, which is only in the primary region. Ensure that you allow connectivity to the fully qualified domain name (FQDN) or IP address of this Azure SQL database in any routes or firewall rules you configure for networks in your secondary regions; the Azure SQL service endpoint can't be used in this scenario. To find the Azure SQL database name in the primary region, go to the Network > Network status page of your API Management instance in the portal.

IP addresses Routing

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