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Showing content from https://github.com/stuart-lab/signac/issues/223 below:

Error message when running FindMotifs() · Issue #223 · stuart-lab/signac · GitHub

Hi Tim,

Thanks a lot for developing this very useful package.

I got an error message when running the code below:

enriched.motifs <- FindMotifs(
    object = signac.object,
    features = da.list[[i]]
  )

Here is the error message: "Testing motif enrichment in 265 regions
Error in smooth.spline(lambda, pi0, df = smooth.df) :
missing or infinite values in inputs are not allowed".

Actually, I used a loop to do motif enrichment for a list of differential accessible peaks. Each list element contains a vector of the DA peaks for a specific cluster. The error only occurs in a specific loop but not all.

I googled this error and I found this link https://support.bioconductor.org/p/105623/
It seems something wrong happens when computing q value. Is there any way to bypass this error or computing q value? I can compute adjusted p-value later after I get all the motif enrichment results.


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