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openpharma/rbmiUtils: Repository for the development of the rbmiUtils package which extends the {rbmi} package for use within clinical trials.

rbmiUtils extends the functionality of rbmi to support more streamlined workflows for multiple imputation in clinical trials. It is designed to simplify key tasks such as analysis execution, pooling, result tidying, and imputed data handling.

• Installation
• Example
• Dataset
• Utilities
• Development Status

You can install the development version of rbmiUtils from cran or GitHub:

This example shows how to run a covariate-adjusted ANCOVA on imputed datasets using Bayesian multiple imputation:

library(dplyr)
library(rbmi)
library(rbmiUtils)

data("ADMI")

# Setup
N_IMPUTATIONS <- 100
WARMUP <- 200
THIN <- 5

# Preprocessing
ADMI <- ADMI %>%
  mutate(
    TRT = factor(TRT, levels = c("Placebo", "Drug A")),
    USUBJID = factor(USUBJID),
    AVISIT = factor(AVISIT)
  )

# Define analysis variables
vars <- set_vars(
  subjid = "USUBJID",
  visit = "AVISIT",
  group = "TRT",
  outcome = "CHG",
  covariates = c("BASE", "STRATA", "REGION")
)

# Specify imputation method
method <- rbmi::method_bayes(
  n_samples = N_IMPUTATIONS,
  control = rbmi::control_bayes(
    warmup = WARMUP,
    thin = THIN
  )
)

# Run analysis
ana_obj <- analyse_mi_data(
  data = ADMI,
  vars = vars,
  method = method,
  fun = ancova
)

# Pool results and tidy
pool_obj <- pool(ana_obj)
tidy_df <- tidy_pool_obj(pool_obj)

# View results
print(tidy_df)
#> # A tibble: 6 × 10
#>   parameter       description visit parameter_type lsm_type     est    se    lci
#>   <chr>           <chr>       <chr> <chr>          <chr>      <dbl> <dbl>  <dbl>
#> 1 trt_Week 24     Treatment … Week… trt            <NA>     -2.17   0.182 -2.53 
#> 2 lsm_ref_Week 24 Least Squa… Week… lsm            ref       0.0782 0.131 -0.179
#> 3 lsm_alt_Week 24 Least Squa… Week… lsm            alt      -2.09   0.126 -2.34 
#> 4 trt_Week 48     Treatment … Week… trt            <NA>     -3.81   0.256 -4.31 
#> 5 lsm_ref_Week 48 Least Squa… Week… lsm            ref       0.0481 0.185 -0.316
#> 6 lsm_alt_Week 48 Least Squa… Week… lsm            alt      -3.76   0.176 -4.11 
#> # ℹ 2 more variables: uci <dbl>, pval <dbl>

The package includes two example datasets for demonstrating imputation and analysis:

• ADEFF: An example efficacy dataset for with missing data.
• ADMI: A large multiple imputation dataset with 100,000 rows and multiple visits, treatment arms, and stratification variables.

Use ?ADEFF and ?ADMI to view full dataset documentation.

Key exported functions include:

• analyse_mi_data(): Applies an analysis function (e.g., ANCOVA) to all imputed datasets.
• tidy_pool_obj(): Tidies and annotates pooled results for reporting.
• get_imputed_data(): Extracts long-format imputed datasets with original subject IDs mapped.

These utilities wrap standard rbmi workflows for improved reproducibility and interpretability.

This package is experimental and under active development. Feedback and contributions are welcome via GitHub issues or pull requests.

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