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Showing content from https://github.com/PeterZZQ/VeloSim below:

PeterZZQ/VeloSim: This package simulates single cell RNA sequencing data during cell developmental process, the simulation includes unspliced RNA count, spliced RNA count, RNA velocity and cell developmental pseudo-time. The simulation can be used to benchmark computational methods including trajectory inference and RNA velocity inference.

VeloSim is a simulation package that generates single-cell RNA Sequencing data for continuous cell developmental process. Given the cell developmental trajectory backbone, e.g. tree, cycle, cycle-tree, etc, VeloSim is able to simulate the whole dynamics of mRNA molecule generation, produces unspliced mRNA count matrix, spliced mRNA count matrix and RNA velocity at the same time. VeloSim can be easily used to benchmark trajectory inference and RNA velocity inference methods.

You can install VeloSim using following command:

devtools::install_github("PeterZZQ/VeloSim")

To learn more about using VeloSim for simulation, please check out three example vignettes below:

• Simulation for cell cycle trajectory
• Simulation for tree-like trajectory
• Simulation for Cycle-tree trajectory

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