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Showing content from https://github.com/Nanostring-Biostats/GeoDiff below:

Nanostring-Biostats/GeoDiff: GeoDiff, an R package for count generating models for analyzing Geomx RNA data. Note that this version of the package is still under development, undergoing submission process to Bioconductor 3.14 release and still needs to complete NanoString internal verification process.

We present GeoDiff, an R package for count generating models for analyzing Geomx RNA data, demonstrated by example data analysis pipeline vignette. The package provides a series of statistical models using count generating distributions for fundamental tasks including background modelling, target and sample QC, normalization and differential expression analysis. The new methods are shown to be more suitable for these tasks in real examples than some conventional methods.

It contains the definition of the NanoStringGeoMxSet class which inherits from Biobase’s ExpressionSet class and NanoStringRCCSet class.

install.packages("devtools")
library("devtools")
devtools::install_github("Nanostring-Biostats/GeoDiff", ref = "dev")

This project is licensed under the MIT license.

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