Author: You Zhou, Kathi Zarnack
Cross-linking immunoprecipitation (CLIP) is a technique that combines UV cross-linking and immunoprecipitation to analyse protein-RNA interactions or to pinpoint RNA modifications (e.g. m6A). CLIP-based methods, such as iCLIP and eCLIP, allow precise mapping of RNA modification sites or RNA-binding protein (RBP) binding sites on a genome-wide scale. These techniques help us to unravel post-transcriptional regulatory networks. In order to make the visualization of CLIP data easier, we develop r Biocpkg("cliProfiler") package. The r Biocpkg("cliProfiler") includes seven functions which allow users easily make different profile plots.
The r Biocpkg("cliProfiler") package is available at https://bioconductor.org and can be installed via BiocManager::install:
if (!require("BiocManager"))
install.packages("BiocManager")
BiocManager::install("cliProfiler")
A package only needs to be installed once. Load the package into an R session with
Documentation (vignette and user manual) is available at the cliProfiler Bioconductor landing page at http://bioconductor.org/packages/cliProfiler.
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