The situation involving the COVID-19 pandemic continues to evolve. There is recent evidence suggesting the potential for coronavirus transmission through droplets and perhaps fecal shedding,1,2 posing potential risks during endoscopy and colonoscopy to other patients, endoscopy personnel, and ourselves.
We provide below important information as well as recommendations to consider in your institutions and practices that provide endoscopy and outpatient GI services:
What we know:1. Cough, fever, fatigue, or sore throat are the most common symptoms in adults
2. The incidence of GI symptoms including nausea and/or diarrhea are uncertain with some reports below 5% and others at 50%.3,4 There have been some reports of isolated diarrhea preceding cough and fever
3. The virus may be present in GI secretions and viral RNA is detectable in stool. Gastrointestinal infection and potential fecal-oral transmission must be considered
4. Asymptomatic spread can occur during the prodromal phase (the mean incubation period is ~5 days, with a range of 0-14 days), with viral shedding greatest when symptoms begin
5. Abnormal liver enzymes are observed in 20-30% of persons with COVID-19 infection
6. Leukocyte counts drop in persons with COVID-19 infection, and elevated WBC is a poor prognostic sign
7. Older people and those listed by the CDC as vulnerable populations, including severe chronic health conditions, such as heart disease, lung disease, diabetes, decompensated cirrhosis, HIV with low CD4 counts, and immunosuppression, (including liver and other solid organ transplant recipients) are at higher risk of developing more serious illness. Pregnancy may be a risk
8. Best protection against virus transmission:
Given the evolving and fluid nature of the situation, institutions, hospitals and clinics have also been formulating their own local guidelines, so we urge you to follow the evolving CDC recommendations and your local requirements.
We plan to work with you and provide updates as appropriate.
The purpose of this communication is to jointly provide you with up to date COVID-19 information in order to maintain the highest level of health and safety for our patients, staff, community, and ourselves.
Additional sources of information: Centers for Disease Control and Prevention (CDC):1. Gu J, Han B, Wang J. COVID-19: Gastrointestinal manifestations and potential fecal-oral transmission. Gastroenterology. 2020 Mar 3. pii: S0016-5085(20)30281-X. [Epub ahead of print] https://doi.org/10.1053/j.gastro.2020.02.054
2. Xiao F, Tang M, et al. Evidence for gastrointestinal infection of SARS-CoV-Gastroenterology. 2020 Mar 3. pii: S0016-5085(20)30282-1. [Epub ahead of print] https://doi.org/10.1053/j.gastro.2020.02.055
3. Huang C, Wang Y, Li X, Ren L, Hao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497-506 https://doi.org/10.1016/S0140-6736(20)30183-5
4. https://www.worldendo.org/2020/02/05/weo-alert-wuhan-proposal-for-safety-in-digestive-endoscopy/
5. https://www.politico.com/news/2020/03/14/surgeon-general-elective-surgeries-coronavirus-129405
6. Repici A, Maselli R Matteo, R, et al. Coronavirus (COVID-19) outbreak: what the department of endoscopy should know. Gastrointest Endosc, March 2020 [Epub ahead of print] https://doi.org/10.1016/j.gie.2020.03.019
We wish you, your families and loved ones strength and good health as we overcome this global pandemic together.
Jorge A. Bezerra, MDRetroSearch is an open source project built by @garambo | Open a GitHub Issue
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