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Showing content from https://en.wikipedia.org/wiki/Loracarbef below:

Loracarbef - Wikipedia

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Chemical compound

Pharmaceutical compound

• J01DC08 (WHO)

• (6R,7S)-7-[[(2S)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

• 76470-66-1 ^Y

• 5284584

• DB00447 ^Y

• 4447634 ^Y

• W72I5ZT78Z

• D08143 ^Y

• ChEMBL1013 ^N

• DTXSID7023223

• Interactive image

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• InChI=1S/C16H16ClN3O4.H2O/c17-9-6-7-10-12(15(22)20(10)13(9)16(23)24)19-14(21)11(18)8-4-2-1-3-5-8;/h1-5,10-12H,6-7,18H2,(H,19,21)(H,23,24);1H2/t10-,11-,12+;/m1./s1

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• Key:GPYKKBAAPVOCIW-HSASPSRMSA-N

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Loracarbef is an antibiotic.^[1] It is a carbacephem, but it is sometimes grouped together with the second-generation cephalosporin antibiotics. Loracarbef is a synthetic "carba" analog of cefaclor, and is more stable.

Loracarbef received FDA approval in 1991 and it was marketed under the trade name Lorabid. Its use was discontinued in 2006.^{[citation needed]}

Loracarbef was used to treat infections of the lungs, maxillary sinuses, throat, skin, and urinary tract.^[2]

Loracarbef had broad spectrum effectiveness against both gram-negative and gram-positive bacteria, including those precipitating infections of the respiratory tract, sinuses, tonsils, skin, urinary tract, and kidneys. It was of specific use in those infections caused by E. coli,S. pyogenes,S. aureus, S. saprophyticus, S. pneumoniae, H. influenzae and M. catarrhalis. ^[3]

Diarrhea is the most common adverse effect with loracarbef. Side effects are more frequently seen with children under the age of twelve.^{[citation needed]}

1. ^ Biedenbach DJ, Jones RN (February 1994). "Predictive accuracy of disk diffusion test for Proteus vulgaris and Providencia species against five newer orally administered cephalosporins, cefdinir, cefetamet, cefprozil, cefuroxime, and loracarbef". Journal of Clinical Microbiology. 32 (2): 559–62. doi:10.1128/JCM.32.2.559-562.1994. PMC 263078. PMID 8150976.
2. ^ "Lorabid (Loracarbef): Uses, Dosage, Side Effects, Interactions, Warning". RxList. Retrieved 2020-06-15.
3. ^ "Loracarbef". www.drugbank.ca. Retrieved 2020-06-15.

• RxList.com - Loracarbef

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