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Lanicemine - Wikipedia

From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Lanicemine (AZD6765) is a low-trapping NMDA receptor antagonist that was under development by AstraZeneca for the management of severe and treatment-resistant depression.[1][2] Lanicemine differs from ketamine in that it is a low-trapping NMDA receptor antagonist, showing similar rapid-acting antidepressant effects to ketamine in clinical trials but with little or no psychotomimetic side effects.[3] However, lanicemine did not meet study endpoints, and its development was terminated by AstraZeneca in 2013.[4]

Ionotropic glutamate receptor modulators AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor KARTooltip Kainate receptor NMDARTooltip N-Methyl-D-aspartate receptor

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