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LS-115509 - Wikipedia
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Chemical compound
Pharmaceutical compound
LS-115509 is an opioid analgesic related to the 4-phenylpiperidine family. It is comparable to drugs such as prodine and pheneridine, but is distinguished by the presence of an ether group and furan ring at the piperidine 4-position, which are not found in other drugs of this class. In animal studies, it has around 2-3x the potency of morphine depending on what assay is used. Like prodine, it has two stereocenters and four possible enantiomers, but the activity of these has not been tested separately.[1][2][3]
- ^ Casy AF, Beckett AH, Hall GH, Vallance DK (December 1961). "Chemistry and pharmacology of 4-alkoxy-piperidines related to reversed esters of pethidine". Journal of Medicinal and Pharmaceutical Chemistry. 4 (3): 535–51. doi:10.1021/jm50019a012. PMID 13877295.
- ^ Beckett AH, Casy AF (February 1965). "Analgesics and their antagonists: biochemical aspects and structure-activity relationships". Progress in Medicinal Chemistry. 4: 171–218. doi:10.1016/s0079-6468(08)70169-3. ISBN 9780444533234. PMID 5319798.
- ^ Lenz GR, Evans SM, Walters DE, Hopfinger AJ (1986). Opiates. Orlando: Academic Press. p. 337. ISBN 978-0-12-443830-9.
Opioid receptor modulators μ-opioid
(MOR) Agonists
(abridged;
full list)
Antagonists
δ-opioid
(DOR) Agonists
Antagonists
κ-opioid
(KOR) Agonists
Antagonists
Nociceptin
(NOP) Agonists
Antagonists
Others
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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