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Fetuin-B - Wikipedia
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Protein-coding gene in the species Homo sapiens
FETUB Identifiers Aliases FETUB, 16G2, Gugu, IRL685, fetuin B External IDs OMIM: 605954; MGI: 1890221; HomoloGene: 8660; GeneCards: FETUB; OMA:FETUB - orthologs Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.3 Start 186,635,969 bp[1] End 186,653,141 bp[1] Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 13.76 cM Start 22,737,084 bp[2] End 22,758,528 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in
- right lobe of liver
- testicle
- skin of abdomen
- skin of leg
- oral cavity
- mucosa of pharynx
- human penis
- vagina
- rectum
- metanephros
Top expressed in
- olfactory epithelium
- esophagus
- left lobe of liver
- zygote
- lip
- secondary oocyte
- primary oocyte
- membranous bone
- molar
- Dermatocranium
More reference expression data BioGPS More reference expression data Gene ontology Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez
26998
59083
Ensembl
ENSG00000090512
ENSMUSG00000022871
UniProt
Q9UGM5
Q9QXC1
RefSeq (mRNA) NM_001308077
NM_001308079
NM_014375
NM_001375587
NM_001375588
NM_001375589
NM_001375590
NM_001375591
NM_001375592
NM_001083904
NM_001083905
NM_021564
RefSeq (protein) NP_001295006
NP_001295008
NP_055190
NP_001362516
NP_001362517
NP_001362518
NP_001362519
NP_001362520
NP_001362521
NP_001077373
NP_001077374
NP_067539
Location (UCSC) Chr 3: 186.64 – 186.65 Mb Chr 16: 22.74 – 22.76 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse
Fetuin-B is a protein that in humans is encoded by the FETUB gene.[5][6]
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells.[6]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000090512 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022871 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP (Jan 2001). "Fetuin-B, a second member of the fetuin family in mammals". Biochem J. 350 Pt 2 (2): 589–97. doi:10.1042/0264-6021:3500589. PMC 1221288. PMID 10947975.
- ^ a b "Entrez Gene: FETUB fetuin B".
- Haidar M, Seddiki N, Gluckman JC, Gattegno L (1993). "Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1". Glycoconj. J. 9 (6): 315–23. doi:10.1007/BF00731092. PMID 1284814. S2CID 7976435.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Denecke B, Gräber S, Schäfer C, et al. (2003). "Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A". Biochem. J. 376 (Pt 1): 135–45. doi:10.1042/BJ20030676. PMC 1223762. PMID 12943536.
- Wajih N, Borras T, Xue W, et al. (2004). "Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin". J. Biol. Chem. 279 (41): 43052–60. doi:10.1074/jbc.M407180200. PMID 15280384.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hsu SJ, Nagase H, Balmain A (2005). "Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity". Genome. 47 (5): 931–46. doi:10.1139/g04-043. PMID 15499407.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Coen G, Ballanti P, Balducci A, et al. (2006). "Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry". Am. J. Kidney Dis. 48 (1): 106–13. doi:10.1053/j.ajkd.2006.03.083. PMID 16797392.
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