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German biophysicist
Claudia Fischbach is a German bioengineer who serves as the James M. and Marsha McCormick Director of Biomedical Engineering and the Stanley Bryer 1946 Professor of Biomedical Engineering at Cornell University. She is Director of the Cornell Physical Sciences Oncology Center on the Physics of Cancer Metabolism.
Early life and education[edit]Fischbach earned a master's degree in pharmacy from the Ludwig Maximilian University of Munich. She worked toward her doctorate in pharmaceutical technology at the University of Regensburg. She then moved to Harvard University, where she worked in tissue engineering.[1]
Research and career[edit]In 2007, Fischbach joined Cornell University,[2] where she started using biomedical engineering to better understand how to treat cancer.[3] The progression of cancer is influenced by interactions with nearby cells and the extracellular matrix. Despite that, the majority of cancer studies do not replicate conditions outside of the body. Fischbach uses tissue engineering to design systems that let her lab model and investigate how these interactions influence tumor cells. She uses model systems to understand the biological strategies tumors adopt to modify bodily function, become more aggressive, and metastasize.[4]
Fischbach has extensively investigated the fundamental mechanisms that underpin breast cancer. For example, she showed that obesity can change the composition of breast tissue, which can promote disease progression.[5][6] Moreover, she was supported by the Human Frontier Science Program to study the impact of breast cancer on the material properties of bone.[7][8] She showed that exercise, which is often prescribed to prevent bone loss, could also help to protect people against metastatic cancer.[9] In addition, her research demonstrated that breast cancer can trigger distant bone growth, which could be a preemptive defense against metastasis.[10]
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