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Showing content from https://doi.org/10.1101/gr.148900 below:

Is “Junk” DNA Mostly Intron DNA?

1. Gane Ka-Shu Wong1,3,
2. Douglas A. Passey1,
3. Ying-zong Huang1,
4. Zhiyong Yang1, and
5. Jun Yu1,2

1. ¹Human Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA; ²Human Genome Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China

Among higher eukaryotes, very little of the genome codes for protein. What is in the rest of the genome, or the “junk” DNA, that, in Homo sapiens, is estimated to be almost 97% of the genome? Is it possible that much of this “junk” is intron DNA? This is not a question that can be answered just by looking at the published data, even from the finished genomes. One cannot assume that there are no genes in a sequenced region, just because no genes were annotated. We introduce another approach to this problem, based on an analysis of the cDNA-to-genomic alignments, in all of the complete or nearly-complete genomes from the multicellular organisms. Our conclusion is that, in animals but not in plants, most of the “junk” is intron DNA.

• ↵3 Corresponding author.

• E-MAIL gksw{at}u.washington.edu; FAX (206) 685–7344.

• Article and publication are at www.genome.org/cgi/doi/10.1101/gr.148900.

• • Received May 23, 2000.
  • Accepted August 29, 2000.
• Cold Spring Harbor Laboratory Press

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