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Showing content from https://doi.org/10.1038/sj.gt.3302020 below:

Gene Therapy Progress and Prospects: Gene therapy in organ transplantation

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  • Guillot C et al. Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4Ig expression. J Immunol 2000; 164: 5258–5268.

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  • Comer RM et al. Effect of administration of CTLA4-Ig as protein or cDNA on corneal allograft survival. Invest Ophthalmol Vis Sci 2002; 43: 1095–1103.

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  • Li TS et al. Prolonged survival of xenograft fetal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression. Transplantation 2001; 72: 1983–1985.

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  • Takehara M et al. Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4IgG and loxP. Hum Gene Ther 2001; 12: 415–426.

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  • Nomura M et al. Induction of donor-specific tolerance by adenovirus-mediated CD40Ig gene therapy in rat liver transplantation. Transplantation 2002; 73: 1403–1410.

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  • Guillot C et al. Prolonged blockade of CD40–CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection. J Immunol 2002; 168: 1600–1609.

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  • Greenwald RJ et al. CTLA-4 regulates induction of anergy in vivo. Immunity 2001; 14: 145–155.

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  • Coyle AJ, Gutierrez-Ramos JC . The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat Immunol 2001; 2: 203–209.

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  • Ozkaynak E et al. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat Immunol 2001; 2: 591–596.

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  • Sykes M . Mixed chimerism and transplant tolerance. Immunity 2001; 14: 417–424.

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  • Sonntag KC et al. Tolerance to solid organ transplants through transfer of MHC class II genes. J Clin Invest 2001; 107: 65–71.

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  • Heim DA et al. Introduction of a xenogeneic gene via hematopoietic stem cells leads to specific tolerance in a rhesus monkey model. Mol Therapy 2000; 1: 533–544.

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  • Bagley J et al. Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy. Blood 2002; 99: 4394–4399.

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  • Kang ES, Iacomini J . Induction of central deletional T cell tolerance by gene therapy. J Immunol 2002; 169: 1930–1935.

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  • Zelenika D et al. The role of CD4+ T-cellsubsets in determining transplantation rejection or tolerance. Immunol Rev 2001; 182: 164–179.

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  • Graca L et al. Both CD4(+)CD25(+) and CD4(+)CD25(−) regulatory cells mediate dominant transplantation tolerance. J Immunol 2002; 168: 5558–5565.

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  • Bracy JL et al. Induction of molecular chimerism by gene therapy prevents antibody mediated heart transplant rejection. Gene Therapy 2001; 8: 1738–1744.

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  • Cretin N et al. The role of T cell help in the production of antibodies specific for Gal alpha 1–3Gal. J Immunol 2002; 168: 1479–1483.

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  • Oshima K et al. Localized interleukin-10 gene transfer induces apoptosis of alloreactive T cells via FAS/FASL pathway, improves function, and prolongs survival of cardiac allograft. Transplantation 2002; 73: 1019–1026.

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  • David A et al. Interleukin-10 produced by recombinant adenovirus prolongs survival of cardiac allografts in rats. Gene Therapy 2000; 7: 505–510.

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  • Hawiger D et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001; 194: 769–779.

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  • Takayama T et al. Retroviral delivery of transforming growth factor-beta1 to myeloid dendritic cells: inhibition of T-cell priming ability and influence on allograft survival. Transplantation 2002; 74: 112–119.

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  • Coates PT et al. Human myeloid dendritic cells transduced with an adenoviral interleukin-10 gene construct inhibit human skin graft rejection in humanized NOD-scid chimeric mice. Gene Therapy 2001; 8: 1224–1233.

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  • Lee WC et al. Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection. Immunology 2000; 101: 233–241.

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  • O'Rourke RW et al. A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival. Transplantation 2000; 69: 1440–1446.

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  • Matsue H et al. Immunosuppressive properties of CD95L-transduced "killer" hybrids created by fusing donor- and recipient-derived dendritic cells. Blood 2001; 98: 3465–3472.

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  • Min WP et al. Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival. J Immunol 2000; 164: 161–167.

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  • Min W et al. Fas ligand-transfected dendritic cells induce apoptosis of antigen-specific T cells. Transplant Proc 2001; 33: 234.

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  • Lehmann TG et al. Delivery of Cu/Zn-superoxide dismutase genes with a viral vector minimizes liver injury and improves survival after liver transplantation in the rat. Transplantation 2000; 69: 1051–1057.

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  • Lehmann TG et al. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Hepatology 2000; 32: 1255–1264.

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  • Kato H et al. Heme oxygenase-1 overexpression protects rat livers from ischemia/reperfusion injury with extended cold preservation. Am J Transplant 2001; 1: 121–128.

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  • Coito AJ et al. Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia–reperfusion injury. Transplantation 2002; 74: 96–102.

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  • Zhu HL et al. Blocking free radical production via adenoviral gene transfer decreases cardiac ischemia–reperfusion injury. Mol Ther 2000; 2: 470–475.

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  • Contreras JL et al. Cytoprotection of pancreatic islets before and early after transplantation using gene therapy. Kidney Int 2002; 61(Suppl 1): 79–84.

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  • Contreras JL et al. Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement. Surgery 2001; 130: 166–174.

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  • Zheng L et al. Cytoprotection of human umbilical vein endothelial cells against apoptosis and CTL-mediated lysis provided by caspase-resistant Bcl-2 without alterations in growth or activation responses. J Immunol 2000; 164: 4665–4671.

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