Puchta, H. Gene replacement by homologous recombination in plants. Plant Mol. Biol. 48, 173–182 (2002)

Article  CAS  PubMed  Google Scholar 

Carroll, D. Progress and prospects: zinc-finger nucleases as gene therapy agents. Gene Ther. 15, 1463–1468 (2008)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iida, S. & Terada, R. Modification of endogenous natural genes by gene targeting in rice and other higher plants. Plant Mol. Biol. 59, 205–219 (2005)

Article  CAS  PubMed  Google Scholar 

Kim, Y. G., Cha, J. & Chandrasegaran, S. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc. Natl Acad. Sci. USA 93, 1156–1160 (1996)

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Puchta, H. The repair of double-strand breaks in plants: mechanisms and consequences for genome evolution. J. Exp. Bot. 56, 1–14 (2005)

Article  CAS  PubMed  Google Scholar 

Jasin, M. Genetic manipulation of genomes with rare-cutting endonucleases. Trends Genet. 12, 224–228 (1996)

Article  CAS  PubMed  Google Scholar 

Bibikova, M. et al. Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. Mol. Cell. Biol. 21, 289–297 (2001)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Porteus, M. H. & Baltimore, D. Chimeric nucleases stimulate gene targeting in human cells. Science 300, 763 (2003)

Article  PubMed  Google Scholar 

Wright, D. A. et al. High-frequency homologous recombination in plants mediated by zinc-finger nucleases. Plant J. 44, 693–705 (2005)

Article  CAS  PubMed  Google Scholar 

Cai, C. Q. et al. Targeted transgene integration in plant cells using designed zinc finger nucleases. Plant Mol. Biol. 69, 699–709 (2008)

Article  PubMed  Google Scholar 

Miller, J., McLachlan, A. D. & Klug, A. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 4, 1609–1614 (1985)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pavletich, N. P. & Pabo, C. O. Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 Å. Science 252, 809–817 (1991)

Article  ADS  CAS  PubMed  Google Scholar 

Isalan, M. & Choo, Y. Rapid, high-throughput engineering of sequence-specific zinc finger DNA-binding proteins. Methods Enzymol. 340, 593–609 (2001)

Article  CAS  PubMed  Google Scholar 

Pabo, C. O., Peisach, E. & Grant, R. A. Design and selection of novel Cys2his2 zinc finger proteins. Annu. Rev. Biochem. 70, 313–340 (2001)

Article  CAS  PubMed  Google Scholar 

Sun, Y. et al. Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from maize: molecular and biochemical characterization. Plant Physiol. 144, 1278–1291 (2007)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raboy, V. Seeds for a better future: ‘low phytate’ grains help to overcome malnutrition and reduce pollution. Trends Plant Sci. 6, 458–462 (2001)

Article  CAS  PubMed  Google Scholar 

Stevenson-Paulik, J. et al. Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Proc. Natl Acad. Sci. USA 102, 12612–12617 (2005)

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Raboy, V. myo-Inositol-1,2,3,4,5,6-hexakisphosphate. Phytochemistry 64, 1033–1043 (2003)

Article  CAS  PubMed  Google Scholar 

Urnov, F. D. et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435, 646–651 (2005)

Article  ADS  CAS  PubMed  Google Scholar 

Gordon-Kamm, W. J. et al. Transformation of maize cells and regeneration of fertile transgenic plants. Plant Cell 2, 603–618 (1990)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frame, B. R. et al. Agrobacterium tumefaciens-mediated transformation of maize embryos using a standard binary vector system. Plant Physiol. 129, 13–22 (2002)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doyon, Y. et al. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nature Biotechnol. 26, 702–708 (2008)

Article  CAS  Google Scholar 

Bibikova, M. et al. Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161, 1169–1175 (2002)

CAS  PubMed  PubMed Central  Google Scholar 

Lloyd, A. et al. Targeted mutagenesis using zinc-finger nucleases in Arabidopsis . Proc. Natl Acad. Sci. USA 102, 2232–2237 (2005)

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Porteus, M. H. Mammalian gene targeting with designed zinc finger nucleases. Mol. Ther. 13, 438–446 (2006)

Article  CAS  PubMed  Google Scholar 

Moehle, E. A. et al. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc. Natl Acad. Sci. USA 104, 3055–3060 (2007)

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Lombardo, A. et al. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nature Biotechnol. 25, 1298–1306 (2007)

Article  CAS  Google Scholar 

Perez, E. E. et al. Establishment of HIV-1 resistance in CD4⁺ T cells by genome editing using zinc-finger nucleases. Nature Biotechnol. 26, 808–816 (2008)

Article  CAS  Google Scholar 

Wei, F. et al. Physical and genetic structure of the maize genome reflects its complex evolutionary history. PLoS Genet. 3, e123 (2007)

Article  PubMed  PubMed Central  Google Scholar 

Maeder, M. L. et al. Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol. Cell 31, 294–301 (2008)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Isalan, M., Klug, A. & Choo, Y. A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter. Nature Biotechnol. 19, 656–660 (2001)

Article  CAS  Google Scholar 

Doyon, Y. et al. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nature Biotechnol. 26, 702–708 (2008)

Article  CAS  Google Scholar 

Maddaloni, M. et al. The sequence of the zein regulatory gene opaque-2 (O2) of Zea mays . Nucleic Acids Res. 17, 7532 (1989)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang, J. et al. Stable antibody expression at therapeutic levels using the 2A peptide. Nature Biotechnol. 23, 584–590 (2005)

Article  CAS  Google Scholar 

Miller, J. C. et al. An improved zinc-finger nuclease architecture for highly specific genome editing. Nature Biotechnol. 25, 778–785 (2007)

Article  CAS  Google Scholar 

Christensen, A. H., Sharrock, R. A. & Quail, P. H. Maize polyubiquitin genes: structure, thermal perturbation of expression and transcript splicing, and promoter activity following transfer to protoplasts by electroporation. Plant Mol. Biol. 18, 675–689 (1992)

Article  CAS  PubMed  Google Scholar 

McElroy, D., Zhang, W., Cao, J. & Wu, R. Isolation of an efficient actin promoter for use in rice transformation. Plant Cell 2, 163–171 (1990)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wohlleben, W. et al. Nucleotide sequence of the phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Nicotiana tabacum . Gene 70, 25–37 (1988)

Article  CAS  PubMed  Google Scholar 

Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning: a Laboratory Manual 2nd edn (Cold Spring Harbor Laboratory Press, 1989)

Google Scholar 

Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2 - ΔΔ C t method. Methods 25, 402–408 (2001)

Article  CAS  PubMed  Google Scholar 

Armstrong, C., Green, C. & Phillips, R. Development and availability of germplasm with high type II culture formation response. Maize Genet. Coop. News Lett. 65, 92–93 (1991)

Google Scholar 

Petolino, J. F., Hopkins, N. L., Kosegi, B. D. & Skokut, M. Whisker-mediated transformation of embryogenic callus of maize. Plant Cell Rep. 19, 781–786 (2000)

Article  CAS  PubMed  Google Scholar 

Skoglund, E., Carlsson, N.-G. & Sandberg, A.-S. Determination of isomers of inositol mono- to hexaphosphates in selected foods and intestinal contents using high-performance ion chromatography. J. Agric. Food Chem. 45, 431–436 (1997)

Article  CAS  Google Scholar 

Stevenson-Paulik, J. et al. Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Proc. Natl Acad. Sci. USA 102, 12612–12617 (2005)

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Buscher, B. A. P., van der Hoeven, R. A. M., Tjaden, U. R., Andersson, E. & Van der Greef, J. Analysis of inositol phosphates and derivatives using capillary zone electrophoresis-mass spectrometry. J. Chromatogr. A 712, 235–243 (1995)

Article  CAS  Google Scholar 

Hsu, F.-F., Turk, J. & Gross, M. L. Structural distinction among inositol phosphate isomers using high-energy and low-energy collisional-activated dissociation tandem mass spectrometry with electrospray ionization. J. Mass Spectrom. 38, 447–457 (2003)

Article  ADS  CAS  PubMed  Google Scholar