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Showing content from https://doi.org/10.1038/2281184a0 below:

Lac Repressor Binding to DNA not containing the Lac Operator and to Synthetic Poly dAT

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• Published: 19 December 1970

Nature volume 228, pages 1184–1186 (1970)Cite this article

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THE lac represser binds very specifically and tightly to the lac operator^1–3. In conditions where the repressor binds to operator with a dissociation constant of 10⁻¹³ M, the binding of represser to DNA not containing the Escherichia coli lac operator (non-operator DNA) was less tight by several orders of magnitude³. Although weak, we thought this non-operator DNA binding could be highly significant and deserved careful study. We report here on the binding of lac represser to non-operator DNA from several natural sources and also to synthetic poly dAT.

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1. Division of Biology, City of Hope National Medical Center, Duarte, California, 91010

   SYR-YAUNG LIN & ARTHUR D. RIGGS

1. SYR-YAUNG LIN
2. ARTHUR D. RIGGS

LIN, SY., RIGGS, A. Lac Repressor Binding to DNA not containing the Lac Operator and to Synthetic Poly dAT. Nature 228, 1184–1186 (1970). https://doi.org/10.1038/2281184a0

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• Received: 04 September 1970

• Revised: 10 October 1970

• Issue Date: 19 December 1970

• DOI: https://doi.org/10.1038/2281184a0

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