To determine whether convergent or trans-specific evolution is responsible for the persistence of the ABO polymorphism in apes, we have sequenced segments of introns 5 and 6 of the ABO gene. Four substitutions and one insertion or deletion group human A, B, and O alleles together, separate from their chimpanzee A and gorilla B counterparts. No shared substitutions support a trans-species mode of evolution for any of the alleles examined. We conclude that the A and B antigens of the chimpanzee and gorilla, respectively, have arisen by convergent evolution. Phylogenetic analysis suggests that the human A and B alleles are ancient, having diverged at least 3 million years ago. These alleles must have therefore been trans-specifically inherited within the genus Homo.
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C. O’hUigin, Akie Sato & Jan Klein
Received: 28 May 1997 / Accepted: 31 July 1997
About this article Cite this articleO’hUigin, C., Sato, A. & Klein, J. Evidence for convergent evolution of A and B blood group antigens in primates. Hum Genet 101, 141–148 (1997). https://doi.org/10.1007/s004390050603
Issue Date: November 1997
DOI: https://doi.org/10.1007/s004390050603
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