Panamesine (PAN) is a nearly specific sigma ligand. Recently, we showed that PAN in doses up to 90 mg/day improved psychometric variables in patients with an acute episode of schizophrenia. No side effects connected to the extrapyramidal motoric system occurred; there was even an absence of daytime sedation. We investigated the effects of PAN on plasma cytokine and soluble cytokine receptor levels and blood cell counts during 4 weeks in ten patients out of the previous study sample. Under PAN treatment, tumor necrosis factor (TNF)-α, soluble TNF receptors p55 and p75, and soluble interleukin-2 receptor levels were not increased and neither were monocyte and lymphocyte counts affected. This absence of immunomodulation is in contrast to clozapine, but similar to haloperidol treatment. In a second study, a single dose of PAN (30 mg) or placebo was administered at 2200 hours to ten young male controls in order to investigate changes in the sleep EEG under the substance. Sleep efficiency index increased, whereas time spent awake decreased. No significant changes in rapid eye movement (REM) sleep or non-REM parameters occurred. The sleep-EEG investigation showed sleep-consolidating effects of the drug, comparable to those of classical neuroleptics. Our results support the hypothesis that the sigma ligand PAN, which has antipsychotic properties, shares biological aspects with haloperidol.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsMax Planck Institute of Psychiatry, Kraepelinstrasse. 10, D-80804 Munich, Germany e-mail: frieboes@mpipsykl.mpg.de, Fax: +49-89-30622-548, , , , , , DE
R.-M. Frieboes, Harald Murck, Irina Antonijevic, Thomas Kraus, Dunja Hinze-Selch, Thomas Pollmächer & Axel Steiger
Received: 28 April 1998/Final version: 26 June 1998
About this article Cite this articleFrieboes, RM., Murck, H., Antonijevic, I. et al. Characterization of the sigma ligand panamesine, a potential antipsychotic, by immune response in patients with schizophrenia and by sleep-EEG changes in normal controls. Psychopharmacology 141, 107–110 (1999). https://doi.org/10.1007/s002130050813
Issue Date: January 1999
DOI: https://doi.org/10.1007/s002130050813
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