A field isolate of Sendai virus, the Hamamatsu strain, was far more virulent in mice than the prototype Z strain. The Hamamatsu strain replicated more efficiently in the mouse lung than the Z strain, causing deteriorating lung lesions. Nucleotide sequence analysis of the HN, F and M genes revealed that the Hamamatsu strain was divergent from the prototype Z, Harris and Fushimi strains.
This is a preview of subscription content, log in via an institution to check access.
Access this article Subscribe and saveSpringer+ Basic
€34.99 /Month
Price includes VAT (Germany)
Instant access to the full article PDF.
Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. ReferencesBlumberg BM, Colomba G, Roux L, Raju R, Dowling P, Chollet A, Kolakofsky D (1985) Sequence determination of the Sendai virus HN gene and its comparison to the influenza virus glycoproteins. Cell 41: 269–278
Blumberg BM, Giorgi C, Rose K, Kolakofsky D (1985) Sequence determination of the Sendai virus fusion protein gene. J Gen Virol 66: 317–331
Blumberg BM, Rose K, Simona MG, Roux L, Giorgi C, Kolakofsky D (1984) Analysis of the Sendai virus M gene and protein. J Virol 52: 626–663
Fukai K, Suzuki T (1955) On the characteristics of a newly-isolated hemagglutinating virus from mice. Med J Osaka Univ 6: 1–15
Hidaka Y, Kanda T, Iwasaki K, Nomoto A, Shioda T, Shibuta H (1984) Nucleotide sequence of a Sendai virus genome region covering the entire M gene and the 3′ proximal 1013 nucleotides of the F gene. Nucleic Acids Res 21: 7965–7973
Ishida N, Homma M (1978) Sendai virus. Adv Virus Res 23: 349–383
Itoh M, Shibuta H, Homma M (1987) Single amino acid substitution of Sendai virus at the cleavage site of the fusion protein confers trypsin resistance. J Gen Virol 68: 2939–2944
Itoh M, Tan DM, Hayashi T, Mochizuki Y, Homma M (1990) Pneumopathogenicity of a Sendai virus protease-activation mutant, TCs, which is sensitive to trypsin and chymotrypsin. J Virol 64: 5660–5664
Kiyotani K, Takao S, Sakaguchi T, Yoshida T (1990) Immediate protection of mice from lethal wild-type Sendai virus (HVJ) infections by a temperature sensitive mutant, HVJpi, possessing homologous interfering capacity. Virology 177:65–74
Kuroya M, Ishida N, Shiratori T (1953) Newborn virus pneumonitis (type Sendai) II report: the isolation of a new virus possessing hemagglutinin activity. Yokohama Med Bull 4:217–233
Mochizuki Y, Tashiro M, Homma M (1988) Pneumopathogenicity in mice of a Sendai virus mutant, TSrev-58, is accompanied by in vitro activation with trypsin. J Virol 62:3040–3042
Neubert WJ, Willenbrink W (1990) Cloning and sequencing of the HN gene of Sendai virus (strain Fushimi). Nucleic Acids Res 18:6427
Sakaguchi T, Toyoda T, Gotoh B, Inocencio NM, Kuma K, Miyata T, Nagai Y (1989) Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene. Virology 169: 260–272
Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
Shioda T, Hidaka Y, Kanda T, Shibuta H, Nomoto A, Iwasaki K (1983) Sequence of 3687 nucleotides from the 3′ end of Sendai virus genome RNA and the predicted amino acid sequences of viral NP, P and C proteins. Nucleic Acids Res 11: 7317–7330
Shioda T, Iwasaki K, Shibuta H (1986) Determination of the complete nucleotide sequence of the Sendai virus genome RNA and the predicted amino acid sequences of the F, HN and L proteins. Nucleic Acids Res 14: 1545–1563
Tashiro M, Homma M (1983) Pneumotropism of Sendai virus in relation to protease-mediated activation in mouse lungs. Infect Immun 39: 879–888
Toyoda T, Sakaguchi T, Hirota H, Gotoh B, Kuma K, Miyata T, Nagai Y (1989) Newcastle disease virus evolution. II. Lack of gene recombination in generating virulent and avirulent strains. Virology 169: 273–282
Van Wyke Coelingh KL, Winter CC, Murphy BR (1988) Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983. Virology 162: 137–143
Willenbrink W, Neubert WJ (1990) Cloning and sequencing of the matrix protein gene (M) of Sendai virus (strain Fushimi). Nucleic Acids Res 18: 3993
Yamaguchi R, Iwai H, Ueda K (1988) Variation of virulence and other properties among Sendai virus strains. Microbiol Immunol 32: 235–240
Department of Bacteriology, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima, Japan
T. Sakaguchi, K. Kiyotani, M. Sakaki, Y. Fujii & T. Yoshida
Sequence data from this report have been deposited with the EMBL/DDBJ/GenBank Data Libraries under accession numbers X57213 and D11446.
About this article Cite this articleSakaguchi, T., Kiyotani, K., Sakaki, M. et al. A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains. Archives of Virology 135, 159–164 (1994). https://doi.org/10.1007/BF01309773
Received: 30 August 1993
Accepted: 08 November 1993
Issue Date: March 1994
DOI: https://doi.org/10.1007/BF01309773
RetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4