P-type ATPases make up a large superfamily of ATP-driven pumps involved in the transmembrane transport of charged substrates. We have performed an analysis of conserved core sequences in 159 P-type ATPases. The various ATPases group together in five major branches according to substrate specificity, and not according to the evolutionary relationship of the parental species, indicating that invention of new substrate specificities is accompanied by abrupt changes in the rate of sequence evolution. A hitherto-unrecognized family of P-type ATPases has been identified that is expected to be represented in all the major phyla of eukarya.
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Similar content being viewed by others Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. Author information Authors and AffiliationsDepartment of Plant Physiology, Institute of Molecular Biology, Copenhagen University, Øster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark, , , , , , DK
Kristian B. Axelsen & Michael G. Palmgren
Received: 21 May 1997 / Accepted: 1 August 1997
About this article Cite this articleAxelsen, K., Palmgren, M. Evolution of Substrate Specificities in the P-Type ATPase Superfamily. J Mol Evol 46, 84–101 (1998). https://doi.org/10.1007/PL00006286
Issue Date: January 1998
DOI: https://doi.org/10.1007/PL00006286
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