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Dependence of antitumor effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells

Abstract

Potent therapeutic effect of hormonal cytostatic cortifen on intracranial brain tumors in rats was demonstrated. The effect was seen after single cortifen course in glioblastoma expressing glucocorticoid receptors and after two courses in glucocorticoid receptor-negative anaplastic astrocytoma. These findings confirmed the concept that selectivity of antitumor drugs can be improved when hormones are used as the carries of cytotoxic groups.

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Author information Authors and Affiliations
  1. N. N. Blokhin Oncology Center, Russian Academy of Medical Sciences, Moscow

    Z. S. Smirnova, Yu. V. Rodionova, E. S. Gershtein & G. K. Gerasimova

  2. Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow

    A. S. Khalanskii

Authors
  1. Z. S. Smirnova
  2. Yu. V. Rodionova
  3. A. S. Khalanskii
  4. E. S. Gershtein
  5. G. K. Gerasimova
Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 331–333, March, 1999

About this article Cite this article

Smirnova, Z.S., Rodionova, Y.V., Khalanskii, A.S. et al. Dependence of antitumor effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells. Bull Exp Biol Med 127, 299–300 (1999). https://doi.org/10.1007/BF02433363

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