Potent therapeutic effect of hormonal cytostatic cortifen on intracranial brain tumors in rats was demonstrated. The effect was seen after single cortifen course in glioblastoma expressing glucocorticoid receptors and after two courses in glucocorticoid receptor-negative anaplastic astrocytoma. These findings confirmed the concept that selectivity of antitumor drugs can be improved when hormones are used as the carries of cytotoxic groups.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 331–333, March, 1999
About this article Cite this articleSmirnova, Z.S., Rodionova, Y.V., Khalanskii, A.S. et al. Dependence of antitumor effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells. Bull Exp Biol Med 127, 299–300 (1999). https://doi.org/10.1007/BF02433363
Received: 01 June 1998
Issue Date: March 1999
DOI: https://doi.org/10.1007/BF02433363
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