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Showing content from https://doi.org/10.1007/BF00620476 below:

99mTc-MAG3, a new renal imaging agent: Preliminary results in patients

^99mTc-mercaptoacetyltriglycine (MAG₃) is a new renal radiopharmaceutical which has been shown to have biological properties similar to¹³¹I-hippurate (OIH) in animals and volunteers.^99mTc-MAG₃ has now been compared with¹³¹I-orthoiodohippurate (OIH) in a group of patients with varying degrees of renal impairment. In all cases, the^99mTc-MAG₃ images were superior regardless of serum creatinine. Selected examples are illustrated including scans and renogram curves in a normal volunteer, transplant patients with creatinines of 9.8 mg/dl and 2.6 mg/dl respectively, and a furosemide study in a patient with questionable obstruction. Our preliminary results suggest that^99mTc-MAG₃ performs well in patients with impaired renal function and may well provide an acceptable replacement for OIH. A kit formulation has been developed and will soon be undergoing clinical evaluation.

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1. Division of Nuclear Medicine, Department of Radiology, Emory University Hospital, 1364 Clifton Road, N.E., 30322, Atlanta, GA, USA

   Andrew Taylor Jr., Dennis Eshima & Naomi Alazraki

1. Andrew Taylor Jr.
2. Dennis Eshima
3. Naomi Alazraki

Taylor, A., Eshima, D. & Alazraki, N. ^99mTc-MAG₃, a new renal imaging agent: Preliminary results in patients. Eur J Nucl Med 12, 510–514 (1987). https://doi.org/10.1007/BF00620476

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• Received: 19 April 1986

• Accepted: 13 September 1986

• Issue Date: October 1987

• DOI: https://doi.org/10.1007/BF00620476

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