Pretreatment with the MAO-inhibitors iproniazid, clorgyline, or deprenyl abolishes the effects of LSD on the conditioned avoidance response (CAR) in rats. The effects of serotonin (5-HT) and 5-methoxytryptamine (5-MT) are greatly potentiated by these substances. Brain levels of LSD are not affected by MAO inhibition whereas levels of 5-HT and 5-MT are significantly elevated. It is postulated that the decreased behavioral response to LSD is the result of ‘MAO inhibitor-induced’ changes whereas the increased response of 5-HT and 5-MT results from increased brain levels of these compounds.
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Explore related subjectsDiscover the latest articles and news from researchers in related subjects, suggested using machine learning. ReferencesAghajanian, G. K., Freedman, D. X.: Biochemical and morphological aspects of LSD pharmacology. In: Psychopharmacology: A Review of Progress 1957–1967, (D. H. Efron, ed.), pp. 1185–1193. Washington: Public Health Service Publication No. 1836, 1968
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Department of Pharmacology, Thomas Jefferson University, 1020 Locust Street, 19107, Philadelphia, PA, USA
Walter C. Prozialeck & Wolfgang H. Vogel
Prozialeck, W.C., Vogel, W.H. MAO inhibition and the effects of centrally administered LSD, serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats. Psychopharmacology 60, 309–310 (1979). https://doi.org/10.1007/BF00426673
Received: 07 March 1978
Accepted: 07 July 1978
Issue Date: January 1979
DOI: https://doi.org/10.1007/BF00426673
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