The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).
Version: 1.4-1 Imports: ggplot2, lattice, mvtnorm Suggests: emmeans, numDeriv, Rsolnp, quadprog, parallel, mmrm, multcomp, knitr, rmarkdown, MASS, testthat (≥ 3.0.0), tibble, RBesT, nlme, dplyr, tidyr Published: 2025-07-09 DOI: 10.32614/CRAN.package.DoseFinding Author: Bjoern Bornkamp [aut], Jose Pinheiro [aut], Frank Bretz [aut], Ludger Sandig [aut], Marius Thomas [aut, cre], Daniel Sabanes Bove [aut], Novartis Pharma AG [cph, fnd] Maintainer: Marius Thomas <marius.thomas at novartis.com> BugReports: https://github.com/openpharma/DoseFinding/issues License: GPL-3 URL: https://github.com/openpharma/DoseFinding, https://openpharma.github.io/DoseFinding/ NeedsCompilation: yes Materials: README NEWS In views: ClinicalTrials, ExperimentalDesign CRAN checks: DoseFinding resultsRetroSearch is an open source project built by @garambo | Open a GitHub Issue
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