Detects and filters damaged cells in single-cell RNA sequencing (scRNA-seq) data using a novel approach inspired by 'DoubletFinder'. Damage is detected by measuring the extent to which cells deviate from artificially damaged profiles of themselves, simulated through the probabilistic escape of cytoplasmic RNA. As output, a damage score ranging from 0 to 1 is given for each cell providing an intuitive scale for filtering that is standardised across cell types, samples, and experiments.
Version: 1.0.0 Depends: R (≥ 4.4.0) Imports: cowplot, dplyr, ggplot2, ggpubr, Matrix, patchwork, scales, RcppHNSW, rlang, tidyr, withr Suggests: Seurat, knitr, rmarkdown, spelling Published: 2025-04-03 DOI: 10.32614/CRAN.package.DamageDetective Author: Alicen Henning [aut, cre, cph] Maintainer: Alicen Henning <alicen.jhb at gmail.com> BugReports: https://github.com/alicenjoyhenning/DamageDetective/issues License: AGPL (≥ 3) URL: https://alicenjoyhenning.github.io/DamageDetective/, https://github.com/alicenjoyhenning/DamageDetective NeedsCompilation: no Language: en-US Materials: NEWS CRAN checks: DamageDetective results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=DamageDetective to link to this page.
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