Simulation is a critical part of method development and assessment in quantitative genetics. 'PhenotypeSimulator' allows for the flexible simulation of phenotypes under different models, including genetic variant and infinitesimal genetic effects (reflecting population structure) as well as non-genetic covariate effects, observational noise and additional correlation effects. The different phenotype components are combined into a final phenotype while controlling for the proportion of variance explained by each of the components. For each effect component, the number of variables, their distribution and the design of their effect across traits can be customised. For the simulation of the genetic effects, external genotype data from a number of standard software ('plink', 'hapgen2'/ 'impute2', 'genome', 'bimbam', simple text files) can be imported. The final simulated phenotypes and its components can be automatically saved into .rds or .csv files. In addition, they can be saved in formats compatible with commonly used genetic association software ('gemma', 'bimbam', 'plink', 'snptest', 'LiMMBo').
Version: 0.3.4 Depends: R (≥ 3.5.0) Imports: methods, optparse, Hmisc, R.utils, mvtnorm, snpStats, zoo, data.table (≥ 1.11.0), Rcpp (≥ 0.12.11), cowplot, ggplot2, reshape2, dplyr LinkingTo: Rcpp Suggests: testthat, knitr, formatR, rmarkdown Published: 2021-07-16 DOI: 10.32614/CRAN.package.PhenotypeSimulator Author: Hannah Meyer [aut, cre], Konrad Rudolph [ctb] Maintainer: Hannah Meyer <hannah.v.meyer at gmail.com> BugReports: https://github.com/HannahVMeyer/PhenotypeSimulator/issues License: MIT + file LICENSE URL: https://github.com/HannahVMeyer/PhenotypeSimulator NeedsCompilation: yes Citation: PhenotypeSimulator citation info Materials: README NEWS CRAN checks: PhenotypeSimulator results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=PhenotypeSimulator to link to this page.
RetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4