A streamlined tool for eplet analysis of donor and recipient HLA (human leukocyte antigen) mismatch. Messy, low-resolution HLA typing data is cleaned, and imputed to high-resolution using the NMDP (National Marrow Donor Program) haplotype reference database <https://haplostats.org/haplostats>. High resolution data is analyzed for overall or single antigen eplet mismatch using a reference table (currently supporting 'HLAMatchMaker' <http://www.epitopes.net> versions 2 and 3). Data can enter or exit the workflow at different points depending on the user's aims and initial data quality.
Version: 1.0.0 Depends: R (≥ 4.1.0) Imports: devtools, tidyverse, dplyr, reshape2, schoolmath, tibble, tidyselect, stringr, purrr, tidyr, utils, readr, janitor Suggests: knitr, rmarkdown Published: 2023-01-31 DOI: 10.32614/CRAN.package.hlaR Author: Joan Zhang [aut, cre], Aileen Johnson [aut], Christian P Larsen [cph, aut] Maintainer: Joan Zhang <joan.zhang at emory.edu> BugReports: https://github.com/LarsenLab/hlaR/issues License: MIT + file LICENSE URL: https://pubmed.ncbi.nlm.nih.gov/35101308/, https://emory-larsenlab.shinyapps.io/hlar_shiny/ NeedsCompilation: no CRAN checks: hlaR results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=hlaR to link to this page.
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