We innovatively defined a pathway mutation accumulate perturbation score (PMAPscore) to reflect the position and the cumulative effect of the genetic mutations at the pathway level. Based on the PMAPscore of pathways, identified prognosis-related pathways altered by somatic mutation and predict immunotherapy efficacy by constructing a multiple-pathway-based risk model (Tarca, Adi Laurentiu et al (2008) <doi:10.1093/bioinformatics/btn577>).
Version: 0.1.1 Depends: R (≥ 4.1.0) Imports: base, clusterProfiler, glmnet, graphics, grDevices, maftools, org.Hs.eg.db, pROC, stats, survival, survminer, utils Suggests: knitr, rmarkdown Published: 2022-04-12 DOI: 10.32614/CRAN.package.PMAPscore Author: Junwei Han [aut, cre, cph], Yalan He [aut], Xiangmei Li [aut] Maintainer: Junwei Han <hanjunwei1981 at 163.com> License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] NeedsCompilation: no CRAN checks: PMAPscore results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=PMAPscore to link to this page.
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