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Showing content from http://www.ncbi.nlm.nih.gov/pubmed/32219356 below:

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

Observational Study

Affiliations

• ¹ Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
• ² Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

• PMID: 32219356
• PMCID: PMC7101506
• DOI: 10.1001/jamacardio.2020.1017

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Observational Study

Tao Guo et al. JAMA Cardiol. 2020.

• ¹ Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
• ² Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

• PMID: 32219356
• PMCID: PMC7101506
• DOI: 10.1001/jamacardio.2020.1017

Item in Clipboard

• Error in Text.

  [No authors listed] [No authors listed] JAMA Cardiol. 2020 Jul 1;5(7):848. doi: 10.1001/jamacardio.2020.1722. JAMA Cardiol. 2020. PMID: 32432683 Free PMC article. No abstract available.

Importance: Increasing numbers of confirmed cases and mortality rates of coronavirus disease 2019 (COVID-19) are occurring in several countries and continents. Information regarding the impact of cardiovascular complication on fatal outcome is scarce.

Objective: To evaluate the association of underlying cardiovascular disease (CVD) and myocardial injury with fatal outcomes in patients with COVID-19.

Design, setting, and participants: This retrospective single-center case series analyzed patients with COVID-19 at the Seventh Hospital of Wuhan City, China, from January 23, 2020, to February 23, 2020. Analysis began February 25, 2020.

Main outcomes and measures: Demographic data, laboratory findings, comorbidities, and treatments were collected and analyzed in patients with and without elevation of troponin T (TnT) levels.

Results: Among 187 patients with confirmed COVID-19, 144 patients (77%) were discharged and 43 patients (23%) died. The mean (SD) age was 58.50 (14.66) years. Overall, 66 (35.3%) had underlying CVD including hypertension, coronary heart disease, and cardiomyopathy, and 52 (27.8%) exhibited myocardial injury as indicated by elevated TnT levels. The mortality during hospitalization was 7.62% (8 of 105) for patients without underlying CVD and normal TnT levels, 13.33% (4 of 30) for those with underlying CVD and normal TnT levels, 37.50% (6 of 16) for those without underlying CVD but elevated TnT levels, and 69.44% (25 of 36) for those with underlying CVD and elevated TnTs. Patients with underlying CVD were more likely to exhibit elevation of TnT levels compared with the patients without CVD (36 [54.5%] vs 16 [13.2%]). Plasma TnT levels demonstrated a high and significantly positive linear correlation with plasma high-sensitivity C-reactive protein levels (β = 0.530, P < .001) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels (β = 0.613, P < .001). Plasma TnT and NT-proBNP levels during hospitalization (median [interquartile range (IQR)], 0.307 [0.094-0.600]; 1902.00 [728.35-8100.00]) and impending death (median [IQR], 0.141 [0.058-0.860]; 5375 [1179.50-25695.25]) increased significantly compared with admission values (median [IQR], 0.0355 [0.015-0.102]; 796.90 [401.93-1742.25]) in patients who died (P = .001; P < .001), while no significant dynamic changes of TnT (median [IQR], 0.010 [0.007-0.019]; 0.013 [0.007-0.022]; 0.011 [0.007-0.016]) and NT-proBNP (median [IQR], 352.20 [174.70-636.70]; 433.80 [155.80-1272.60]; 145.40 [63.4-526.50]) was observed in survivors (P = .96; P = .16). During hospitalization, patients with elevated TnT levels had more frequent malignant arrhythmias, and the use of glucocorticoid therapy (37 [71.2%] vs 69 [51.1%]) and mechanical ventilation (31 [59.6%] vs 14 [10.4%]) were higher compared with patients with normal TnT levels. The mortality rates of patients with and without use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers was 36.8% (7 of 19) and 21.4% (36 of 168) (P = .13).

Conclusions and relevance: Myocardial injury is significantly associated with fatal outcome of COVID-19, while the prognosis of patients with underlying CVD but without myocardial injury is relatively favorable. Myocardial injury is associated with cardiac dysfunction and arrhythmias. Inflammation may be a potential mechanism for myocardial injury. Aggressive treatment may be considered for patients at high risk of myocardial injury.

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Conflict of Interest Disclosures: None reported.

Plasma troponin T (TnT), high-sensitivity…

Plasma troponin T (TnT), high-sensitivity C-reactive protein levels (hsCRP), and N-terminal pro–brain natriuretic peptide (NT-pro BNP) collected on admission.

The horizontal lines represent the…

The horizontal lines represent the median value in each group. NT-proBNP indicates N-terminal pro–brain natriuretic peptide; TnT, troponin T.

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  Golomb MR, Hall GC. Golomb MR, et al. Stroke. 2020 Jul;51(7):e138. doi: 10.1161/STROKEAHA.120.030251. Epub 2020 May 18. Stroke. 2020. PMID: 32421393 Free PMC article. No abstract available.

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  Nai Fovino L, Cademartiri F, Tarantini G. Nai Fovino L, et al. Eur Heart J Cardiovasc Imaging. 2020 Sep 1;21(9):1055-1056. doi: 10.1093/ehjci/jeaa202. Eur Heart J Cardiovasc Imaging. 2020. PMID: 32671381 Free PMC article. No abstract available.

• Acute Fulminant Myocarditis in a Pediatric Patient With COVID-19 Infection.

  Lara D, Young T, Del Toro K, Chan V, Ianiro C, Hunt K, Kleinmahon J. Lara D, et al. Pediatrics. 2020 Aug;146(2):e20201509. doi: 10.1542/peds.2020-1509. Pediatrics. 2020. PMID: 32747591

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  Laleh Far V, Mehrakizadeh A, Eslami M, Shirazi S, Mohammadi M, Mollazadeh R. Laleh Far V, et al. Pol Arch Intern Med. 2020 Nov 30;130(11):1010-1012. doi: 10.20452/pamw.15601. Epub 2020 Sep 15. Pol Arch Intern Med. 2020. PMID: 32930544 No abstract available.

• Myocardial Injury in COVID-19-Can We Successfully Target Inflammation?

  Giannopoulos G, Vrachatis DA, Deftereos SG. Giannopoulos G, et al. JAMA Cardiol. 2020 Sep 1;5(9):1069-1070. doi: 10.1001/jamacardio.2020.2569. JAMA Cardiol. 2020. PMID: 32936267 No abstract available.

• McConnell's sign assessed by point-of-care cardiac ultrasound associated with in-hospital mortality of COVID-19 patients with respiratory failure.

  Doi S, Izumo M, Shiokawa N, Teramoto K, Ishibashi Y, Higuma T, Fujitani S, Akashi YJ. Doi S, et al. J Echocardiogr. 2021 Mar;19(1):67-69. doi: 10.1007/s12574-020-00507-4. Epub 2021 Jan 16. J Echocardiogr. 2021. PMID: 33452995 Free PMC article. No abstract available.

• Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.

  Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, Huang H, Yang B, Huang C. Shi S, et al. JAMA Cardiol. 2020 Jul 1;5(7):802-810. doi: 10.1001/jamacardio.2020.0950. JAMA Cardiol. 2020. PMID: 32211816 Free PMC article.

• Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis.

  Wei JF, Huang FY, Xiong TY, Liu Q, Chen H, Wang H, Huang H, Luo YC, Zhou X, Liu ZY, Peng Y, Xu YN, Wang B, Yang YY, Liang ZA, Lei XZ, Ge Y, Yang M, Zhang L, Zeng MQ, Yu H, Liu K, Jia YH, Prendergast BD, Li WM, Chen M. Wei JF, et al. Heart. 2020 Aug;106(15):1154-1159. doi: 10.1136/heartjnl-2020-317007. Epub 2020 Apr 30. Heart. 2020. PMID: 32354798 Free PMC article.

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  Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Wang D, et al. JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585. JAMA. 2020. PMID: 32031570 Free PMC article.

• Cardiac injuries in coronavirus disease 2019 (COVID-19).

  Chen C, Li H, Hang W, Wang DW. Chen C, et al. J Mol Cell Cardiol. 2020 Aug;145:25-29. doi: 10.1016/j.yjmcc.2020.06.002. Epub 2020 Jun 8. J Mol Cell Cardiol. 2020. PMID: 32526224 Free PMC article. Review.

• Potential Effects of Coronaviruses on the Cardiovascular System: A Review.

  Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Madjid M, et al. JAMA Cardiol. 2020 Jul 1;5(7):831-840. doi: 10.1001/jamacardio.2020.1286. JAMA Cardiol. 2020. PMID: 32219363 Review.

• Drug-utilisation profiles and COVID-19.

  Orlando V, Coscioni E, Guarino I, Mucherino S, Perrella A, Trama U, Limongelli G, Menditto E. Orlando V, et al. Sci Rep. 2021 Apr 26;11(1):8913. doi: 10.1038/s41598-021-88398-y. Sci Rep. 2021. PMID: 33903671 Free PMC article.

• SARS-CoV 2 Infection (Covid-19) and Cardiovascular Disease in Africa: Health Care and Socio-Economic Implications.

  Ogah OS, Umuerri EM, Adebiyi A, Orimolade OA, Sani MU, Ojji DB, Mbakwem AC, Stewart S, Sliwa K. Ogah OS, et al. Glob Heart. 2021 Mar 15;16(1):18. doi: 10.5334/gh.829. Glob Heart. 2021. PMID: 33833942 Free PMC article. Review.

• Cardiac markers of multisystem inflammatory syndrome in children (MIS-C) in COVID-19 patients: A meta-analysis.

  Zhao Y, Patel J, Huang Y, Yin L, Tang L. Zhao Y, et al. Am J Emerg Med. 2021 Nov;49:62-70. doi: 10.1016/j.ajem.2021.05.044. Epub 2021 May 18. Am J Emerg Med. 2021. PMID: 34082189 Free PMC article.

• Clinical Presentation of Patients Infected with Coronavirus Disease 19: A Systematic Review.

  Sheleme T, Bekele F, Ayela T. Sheleme T, et al. Infect Dis (Auckl). 2020 Sep 10;13:1178633720952076. doi: 10.1177/1178633720952076. eCollection 2020. Infect Dis (Auckl). 2020. PMID: 32973375 Free PMC article. Review.

• Heart failure in COVID-19 patients: prevalence, incidence and prognostic implications.

  Rey JR, Caro-Codón J, Rosillo SO, Iniesta ÁM, Castrejón-Castrejón S, Marco-Clement I, Martín-Polo L, Merino-Argos C, Rodríguez-Sotelo L, García-Veas JM, Martínez-Marín LA, Martínez-Cossiani M, Buño A, Gonzalez-Valle L, Herrero A, López-Sendón JL, Merino JL; CARD-COVID Investigators. Rey JR, et al. Eur J Heart Fail. 2020 Dec;22(12):2205-2215. doi: 10.1002/ejhf.1990. Epub 2020 Oct 7. Eur J Heart Fail. 2020. PMID: 32833283 Free PMC article.

1. 1. Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol. 2020;92(4):401-402. doi:10.1002/jmv.25678 - DOI - PMC - PubMed
2. 1. Hui DS, I Azhar E, Madani TA, et al. . The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health: the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264-266. doi:10.1016/j.ijid.2020.01.009 - DOI - PMC - PubMed
3. 1. Paules CI, Marston HD, Fauci AS. Coronavirus infections: more than just the common cold. JAMA. Published online January 23, 2020. doi:10.1001/jama.2020.0757 - DOI - PubMed
4. 1. Wuhan Municipal Health Commission. Report of clustering pneumonia of unknown etiology in Wuhan City. Published December 31, 2019. Accessed January 31, 2020. http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989
5. 1. Huang C, Wang Y, Li X, et al. . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5 - DOI - PMC - PubMed

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