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Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement

Review

Affiliations

• ¹ Canada Research Chair in Human Genome Epidemiology, Toronto, ON, Canada. jlittle@uottawa.ca

• PMID: 19189221
• PMCID: PMC2764094
• DOI: 10.1007/s10654-008-9302-y

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Review

Julian Little et al. Eur J Epidemiol. 2009.

• ¹ Canada Research Chair in Human Genome Epidemiology, Toronto, ON, Canada. jlittle@uottawa.ca

• PMID: 19189221
• PMCID: PMC2764094
• DOI: 10.1007/s10654-008-9302-y

Item in Clipboard

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

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• STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement.

  Little J, Higgins JP, Ioannidis JP, Moher D, Gagnon F, von Elm E, Khoury MJ, Cohen B, Davey-Smith G, Grimshaw J, Scheet P, Gwinn M, Williamson RE, Zou GY, Hutchings K, Johnson CY, Tait V, Wiens M, Golding J, van Duijn C, McLaughlin J, Paterson A, Wells G, Fortier I, Freedman M, Zecevic M, King R, Infante-Rivard C, Stewart A, Birkett N. Little J, et al. Ann Intern Med. 2009 Feb 3;150(3):206-15. doi: 10.7326/0003-4819-150-3-200902030-00011. Ann Intern Med. 2009. PMID: 19189911

• STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement.

  Little J, Higgins JP, Ioannidis JP, Moher D, Gagnon F, von Elm E, Khoury MJ, Cohen B, Davey-Smith G, Grimshaw J, Scheet P, Gwinn M, Williamson RE, Zou GY, Hutchings K, Johnson CY, Tait V, Wiens M, Golding J, van Duijn C, McLaughlin J, Paterson A, Wells G, Fortier I, Freedman M, Zecevic M, King R, Infante-Rivard C, Stewart A, Birkett N. Little J, et al. Eur J Clin Invest. 2009 Apr;39(4):247-66. doi: 10.1111/j.1365-2362.2009.02125.x. Eur J Clin Invest. 2009. PMID: 19297801 Free PMC article.

• Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement.

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• Evaluation of the Endorsement of the STrengthening the REporting of Genetic Association Studies (STREGA) Statement on the Reporting Quality of Published Genetic Association Studies.

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