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Showing content from http://www.ncbi.nlm.nih.gov/pubmed/12138603 below:

Issues in the approval of, access to, and post-marketing follow-up of new drugs in Canada: a personal viewpoint

Cardiovascular safety of drugs not intended for cardiovascular use: need for a new conceptual basis for assessment and approval.

Borer JS, Pouleur H, Abadie E, Follath F, Wittes J, Pfeffer MA, Pitt B, Zannad F. Borer JS, et al. Eur Heart J. 2007 Aug;28(15):1904-9. doi: 10.1093/eurheartj/ehm209. Epub 2007 Jul 5. Eur Heart J. 2007. PMID: 17615083 Review.

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